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Platelet-Activating Factor and Related Lipid Mediators pp 375–402Cite as

Functions of PAF in Reproduction and Development: Involvement of PAF in Fetal Lung Maturation and Parturition

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Abstract

The first suggestion that PAF may be involved in the process of reproduction was based on the observation that PAF appeared in human amniotic fluid in association with labor (Billah and Johnston, 1983). Nishihira and colleagues (1984) confirmed these observations and demonstrated that strips of rat myometrium contracted in response to PAF at concentrations similar to those present in amniotic fluid. In addition to the potential role of PAF in parturition, PAF may also be involved in nidation. Recently, O’Neill (1985a,b) suggested that the thrombocytopenia associated with early pregnancy in the mouse may be related to the production of PAF by the fertilized egg. Furthermore, Angle et al. (1985) reported that on the 6th day of pregnancy in the rabbit, the amount of PAF in the endometrium is ten times greater than that in endometrium of nonpregnant rabbits. These observations are suggestive that PAF may be involved in the changes in vascular permeability that are essential for nidation. Thus, it appears that PAF may participate in the various stages of reproduction ranging from implantation of the fertilized egg to the initiation of parturition.

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Authors and Affiliations

  1. Departments of Biochemistry and Obstetrics-Gynecology and The Cecil H. and Ida Green Center for Reproductive Biology Sciences, The University of Texas Health Science Center, Dallas, Texas, 75235, USA

    John M. Johnston, John E. Bleasdale & Dennis R. Hoffman

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  1. John M. Johnston
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  2. John E. Bleasdale
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  3. Dennis R. Hoffman
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  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder Ph.D

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Johnston, J.M., Bleasdale, J.E., Hoffman, D.R. (1987). Functions of PAF in Reproduction and Development: Involvement of PAF in Fetal Lung Maturation and Parturition. In: Snyder, F. (eds) Platelet-Activating Factor and Related Lipid Mediators. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5284-6_18

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