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The Role of Platelet-Activating Factor in Inflammation

  • Chapter
Platelet-Activating Factor and Related Lipid Mediators

Abstract

Inflammation and hypersensitivity reactions are reactions of vascularized tissue to exogenous or endogenous noxa. Inflammation suggests a protective, immunologically or nonimmunologically mediated response that tends first to localize and then to neutralize noxious material. The inflammatory response is strictly intertwined with a complex series of events that serve to heal and repair the damaged tissue. However, inflammation and repair may be potentially harmful. Hypersensitivity reactions imply an incongruous or sustained activation of the immunologic reactions involved in the inflammatory response, which results not in protection, but in destruction of tissue integrity.

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Authors and Affiliations

  1. Laboratory of Immunopathology, Chair of Nephrology, University of Turin, Turin, Italy

    Giovanni Camussi & Jan R. Brentjens

  2. Departments of Microbiology, Pathology, and Medicine, State University of New York, Buffalo, New York, 14214, USA

    Giovanni Camussi & Jan R. Brentjens

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  1. Giovanni Camussi
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  2. Jan R. Brentjens
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Editors and Affiliations

  1. Medical and Health Sciences Division, Oak Ridge Associated Universities, Oak Ridge, Tennessee, 37831, USA

    Fred Snyder Ph.D

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Camussi, G., Brentjens, J.R. (1987). The Role of Platelet-Activating Factor in Inflammation. In: Snyder, F. (eds) Platelet-Activating Factor and Related Lipid Mediators. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5284-6_14

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  • DOI: https://doi.org/10.1007/978-1-4684-5284-6_14

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