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Neoplastic Transformations

Possible Unexplored Functions of Cytoskeleton

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Book cover Cytoskeleton

Part of the book series: Cellular Organelles ((CORG))

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Abstract

There are at least two reasons why neoplastic transformations of one particular cell type, cultured fibroblasts, deserve special discussion in a book on the cytoskeleton. First, these transformations are the best-studied genetic changes of cells of higher eukaryotes, manifested by alterations of morphogenesis. Therefore, analysis of these changes can help further our understanding of the mechanisms of regulation of morphogenesis. Second, neoplastic transformations are manifested not only by morphological changes, but also by alterations of growth regulation. Therefore, analysis of the expression of neoplastic transformations can help to reveal the possible relationship of the cytoskeleton to this regulation and, more generally, to the control of biochemical reorganizations of the cell.

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Authors and Affiliations

  1. Cancer Research Center, Moscow State University, Moscow, USSR

    Alexander D. Bershadsky & Juri M. Vasiliev

Authors
  1. Alexander D. Bershadsky
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  2. Juri M. Vasiliev
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© 1988 Plenum Press, New York

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Bershadsky, A.D., Vasiliev, J.M. (1988). Neoplastic Transformations. In: Cytoskeleton. Cellular Organelles. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5278-5_10

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  • DOI: https://doi.org/10.1007/978-1-4684-5278-5_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5280-8

  • Online ISBN: 978-1-4684-5278-5

  • eBook Packages: Springer Book Archive

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