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Disturbed Phosphate Metabolism in Spontaneously Hypertensive Rats

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Phosphate and Mineral Homeostasis

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 208))

Abstract

In spontaneously hypertensive rats (SHR) Ca2+ metabolism is abnormal when compared to normotensive Wistar-Kyoto rats (WKY). Disturbances in Ca2+ metabolism include a slight decrease in serum ionized Ca2+ concentration (McCarron et al., 1981; Wright and Rankin, 1982), hypercalciuria (McCarron et al., 1981; Bindels et al., 1984) and increased serum parathyroid hormone (PTH) levels (McCarron et al., 1981; Anderson et al., 1983). Finally, a high Ca2+ diet lowers the blood pressure in SHR (McCarron et al., 1981) after 18 weeks, proving the functional importance of the disturbed Ca2+ homeostasis in SHR.

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Author information

Authors and Affiliations

  1. Department of Physiology, University of Nijmegen, P.O.Box 9101, 6500 HB, Nijmegen, The Netherlands

    R. J. M. Bindels & C. H. van Os

Authors
  1. R. J. M. Bindels
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  2. C. H. van Os
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. University of Aix-Marseille, Marseille, France

    Michel Olmer

  3. University of Heidelberg, Heidelberg, Federal Republic of Germany

    Eberhard Ritz

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© 1986 Plenum Press, New York

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Bindels, R.J.M., van Os, C.H. (1986). Disturbed Phosphate Metabolism in Spontaneously Hypertensive Rats. In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_52

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  • DOI: https://doi.org/10.1007/978-1-4684-5206-8_52

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5208-2

  • Online ISBN: 978-1-4684-5206-8

  • eBook Packages: Springer Book Archive

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