Abstract
The circulating level of 1,25(OH)2D3 (calcitriol) which controls intestinal absorption of calcium, has been suggested to play a major role in the clinical presentation of primary hyperparathyroidism (PHPT) (Broadus et al., 1980). In a recent report (Broadus et al., 1980), abnormally high circulating values of calcitriol were found in the absorptive form of the disease, characterized by high intestinal absorption of calcium, hypercalciuria, high incidence of renal stones, whereas normal to high-normal values of calcitriol were observed in non-absorptive form of the disease, with normal intestinal absorption of calcium, normal calciuria and low incidence of renal stones. However, the differences in serum calcitriol values could not be explained on the basis of differences in any of the variables currently regarded as modulating the renal production of calcitriol (Broadus et al., 1980).
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References
Armbrecht, H. J., Wongsurawat, N., Zenser, T. V., and Davis, B.B. 1984, Effect of PTH and 1,25 (OH)2D3 on renal 25 (OH) D3 metabolism, adenylate cyclase and protein kinase, Am. J. Physiol., 246: E102–E107.
Bouillon, R., De Moor, P., Baggiolini, E.G., and Uskokovic, M.R. 1980, A radioimmunoassay for 1,25 dihydroxycholecalciferol, Clin. Chem., 26: 562–567.
Broadus, A. E., Mahaffey, J. E., Bartter, F. C., and Neer, R. M. 1977, Nephrogenous cyclic Adenosine Monophosphate as a parathyroid function test, J. Clin. Invest., 60: 771–783.
Broadus, A. E., Horst, R. L., Lang, R., Littledike, E. T., and Rasmussen, H. 1980, The importance of circulating 1,25 dihydroxyvitamin D in the pathogenesis of hypercalcemia and renal-stone formation in primary hyperparathyroidism, New Engl. J. Med., 302: 421–425.
Gardin, J. P., Paillard, M. 1984, Normocalcemic primary hyperparathyroidism. Resistance to PTH effect on tubular reabsorption of calcium, Mineral Electrolyte Metab., 10: 301–308.
Kaplan, R. A., Haussier, M. R., Deftos, L. J., Bone, H., and Pak, C. Y. C. 1977, The role of 1 alpha 25 dihydroxyvitamin D in the mediation of intestinal hyperabsorption of calcium in primary hyperparathyroidism and absorptive hypercalciuria, J. Clin. Invest., 59: 756–760.
Kawashima, H., and Kurokawa, K. 1983, Unique hormonal regulation of vitamin D metabolsm in the Mammalian kidney, Mineral Electrolyte Metab., 9: 227–235.
Keh Sung Tsai, Heath III, H., Kumar, R., and Riggs, B.L. 1984, Impaired vitamin D metabolism with aging in women. Possible role in pathogenesis of senile osteoporosis, J. Clin. Invest., 73: 1668–1672.
Manolagas, C., Culler, F. L., Howard, J. E., Brickman, A. S., and Deftos, J. 1983, The cytoreceptor assay for 1,25 dihydroxyvitamin D and its application to clinical studies, J. Clin. Endocrinol. Metab., 56: 751–760.
Preece, M.A., O’Riordan, J. L. H., Lawson, D. E. M., and Koticed, E. 1974, A competitive protein binding assay for 25 hydroxycholecalciferol and 25-hydroxyergocalciferol in serum, Clin. Chim. Acta, 54: 235–242.
Rowe, J. W., Andres, R., Tobin, J.D., Norris, A.H., and Shock, N. W. 1976, The effect of age on creatinine clearance in man: a cross-sectional and longitudinal study, J. Geront., 31: 155–163.
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© 1986 Plenum Press, New York
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Paillard, M., Patron, P., Gardin, J.P. (1986). Determinants of Circulating Levels of 1.25(OH)2D3 (Calcitriol) in Primary Ry Hyperparathyroidism (PHPT). In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_46
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DOI: https://doi.org/10.1007/978-1-4684-5206-8_46
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