Abstract
The bone GLA protein (BGP) or osteocalcin, is a vitamin K-dependent protein produced by the osteoblasts (1), which accumulates in the non-collagenous protein fraction of bone, but it is also measurable by radioimmunoassay in the serum (2). In vitro (1) and experimental in vivo studies (3) have shown that production of this protein is modulated by 1,25(OH)2D3. However a basal production of BGP can be observed even in the vitamin D depleted animal (3). In predialysis chronic renal failure serum BGP levels are higher than normal (4) in spite of the known 1,25(OH)2D3 deficit (5).
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© 1986 Plenum Press, New York
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Coen, G. et al. (1986). Effects of 1,25(OH)2D3 Administration on Serum Bone GLA Protein in Predialysis Chronic Renal Failure. In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_38
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DOI: https://doi.org/10.1007/978-1-4684-5206-8_38
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