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Phosphate and Mineral Homeostasis pp 291–296Cite as

Serum Bone Gla-Protein Compared to Bone Histomorphometry in Hemodialyzed Patients

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 208))

Abstract

Bone gla-protein (BGP), also called osteocalcin1,2, is the most abundant non-collagenous bone protein. BGP is synthesized by the osteoblasts, is concentrated in the bone matrix and also found circulating in the blood. The measurement of BGP in serum by radioimmunoassay3 has proved to be a useful tool for assessing bone turnover in a variety of metabolic or endocrine bone diseascs4–6 and more specifically bone formation in osteoporosis7.

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References

  1. P.F. Hauschka, J.B. Lian and P.M. Gallop, Direct identifica-tion of the calcium binding amino acid-carboxyglutamate in mineralized tissue, Proc. Natl. Acad. Sci. USA 72: 3925 (1975)

    Article  Google Scholar 

  2. P.A. Price, A.S. Otsuka, J.W. Poser, J. Kristaponis and N. Ramin, Characterization of a gamma-carboxyglutamic acid-containing protein from bone, Proc. Natl. Acad. Sci. USA 73: 1147 (1976)

    Google Scholar 

  3. P.A. Price and S.K. Nishimoto, Radioimmunoassay for the vitamin K-dependent protein of bone and its discovery in plasma, Proc. Natl. Acad. Sci. USA 77: 2234 (1980)

    Article  Google Scholar 

  4. P.A. Price, J.G. Parthemore and L.J. Deftos, New biochemical marker for bone metabolism. Measurement by radioimmunoassay of bone gla-protein in the plasma of normal subjects and patients with bone disease, J. Clin. Invest, 66: 878 (1980)

    Article  Google Scholar 

  5. P. Delmas, H.W. Wahner, K.G. Mann and B.L. Riggs, Assessment of bone turnover in postmenopausal osteoporosis by measurement of serum bone gla-protein, J. Lab. Clin. Med. 102: 470 (1983)

    Google Scholar 

  6. H.H. Malluche, M.C. Faugere, P. Fanti and P.A. Price, Plasma levels of bone gla-protein reflect bone formation in patients on chronic maintenance hemodialysis, Kidney Int. 26: 869 (1984)

    Article  Google Scholar 

  7. J.P. Brown, P.D. Delmas, L. Malaval, C. Edouard, M.C. Chapuy and P.J. Meunier, Serum bone gla-protein: a specific marker for bone formation in post menopausal osteoporosis, Lancet, i: 1091 (1984)

    Google Scholar 

  8. S.A. Charhon, Y.F. Berland, M.J. Olmer, E. Delawari, J. Traeger and P.J. Meunier, Effects of parathyroidectomy on bone formation and mineralization in hemodialyzed patients, Kidney Int., 27: 426 (1985)

    Article  Google Scholar 

  9. S.A. Charhon, P.M. Chavassieux, M.C. Chapuy, G.Y. Boivin and P.J. Meunier, Low rate of bone formation with or without histological appearance of osteomalacia in patients with aluminum intoxication, J. Lab. Clin. Med. (1985, in press)

    Google Scholar 

  10. P.D. Delmas, D. Stenner, H.W. Wahner, K.G. Mann and B.L. Riggs, Increase in serum bone gamma-carboxyglutamic acid protein with aging in women, J. Clin. Invest. 71: 1316 (1983)

    Article  Google Scholar 

  11. P.D. Delmas, D.M. Wilson, K.G. Mann and B.L. Riggs, Effect of renal function of plasma levels of bone gla-protein, J. Clin. Endocrinol. Metab. 57: 1028 (1983)

    Article  Google Scholar 

  12. H.H. Conaway and C.S. Anast, Double antibody radioimmunoassay for parathyroid hormone, J. Lab. Clin. Med. 83: 129 (1974)

    Google Scholar 

  13. Y. Pegon, Dosage de l’aluminium dans les liquides biologiques par absorption atomique sans flamme, Anal. Chim. Acta. 101: 385 (1978)

    Article  Google Scholar 

  14. P.J. Meunier, Bone biopsy in diagnosis of metabolic bone disease, in: “Hormonal control of calcium metabolism” D. V. Cohn, R.V. Talmage and J. Les Matthews, eds, Excerpta Medica, Amsterdam (1980)

    Google Scholar 

  15. N.A. Maloney, S.M. Ott, A.C. Alfrey, N.L. Milliner, J.W. Coburn and D.J. Sherrard, Histological quantitation of aluminum in iliac bone from patients with renal failure, J. Lab. Clin. Med. 99: 206 (1982)

    Google Scholar 

  16. A.K. Cheung, S.C. Manolagas, B.D. Catherwood, C.A. Mosely Jr, J.A. Mitas III, R.C. Blantz and L.J. Deftos, Determinants of serum 1,25(OH)2D levels in renal disease, Kidney Int. 24: 104 (1983)

    Article  Google Scholar 

  17. S. Epstein, H. Traberg, R. Raja and J. Poser, Serum and dialysate osteocalcin levels in hemodialysis and peritoneal dialysis patients and after renal transplantation, J. Clin. Endocrinol. Metab. 60: 1253 (1985)

    Article  Google Scholar 

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Authors and Affiliations

  1. INSERM U 234, Faculté A. Carrel, Lyon, France

    Sam A. Charhon, Pierre D. Delmas, Luc Malaval, Pascale M. Chavassieux, Marie Claire Chapuy & Pierre J. Meunier

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  1. Sam A. Charhon
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  2. Pierre D. Delmas
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  3. Luc Malaval
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  4. Pascale M. Chavassieux
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  5. Marie Claire Chapuy
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  6. Pierre J. Meunier
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Editor information

Editors and Affiliations

  1. University of Southern California, Los Angeles, California, USA

    Shaul G. Massry

  2. University of Aix-Marseille, Marseille, France

    Michel Olmer

  3. University of Heidelberg, Heidelberg, Federal Republic of Germany

    Eberhard Ritz

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© 1986 Plenum Press, New York

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Charhon, S.A., Delmas, P.D., Malaval, L., Chavassieux, P.M., Chapuy, M.C., Meunier, P.J. (1986). Serum Bone Gla-Protein Compared to Bone Histomorphometry in Hemodialyzed Patients. In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_37

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  • DOI: https://doi.org/10.1007/978-1-4684-5206-8_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5208-2

  • Online ISBN: 978-1-4684-5206-8

  • eBook Packages: Springer Book Archive

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