Skip to main content

Possible Role of Calcium in Parathyroid Hormone Action on Phosphate Transport in Rabbit Renal Proximal Tubules

  • Chapter
  • 136 Accesses

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 208))

Abstract

In the renal proximal tubule, parathyroid hormone (PTH) stimulates gluconeogenesis (GNG) and suppresses fluid and phosphate reabsorption. Since PTH stimulates cAMP formation in this nephron segment, and the administration of cAMP reproduces hormonal actions, it is generally accepted that PTH exerts its biological effects through cAMP as the intracellular messenger.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. D. Chabardes, M. Imbert, A. Clique, M. Montegut, F. Morel., PTH sensitive adenyl cyclase activity in different segments of the rabbit nephron, Pfluegers Arch 345: 229 – 239 (1975).

    Google Scholar 

  2. V.W. Dennis, E. Bello-Reuss, R.R. Robinson, Response of phosphate transport to parathyroid hormone in segments of rabbit nephron, Am. J. Physiol. 233: F29 – F38 (1977).

    Google Scholar 

  3. Ok Jo, N. Yanagawa, Absence of parathyroid hormone effect on gluconeogenesis in rabbit proximal convoluted tubules, Kidney Int. 25: 266 (1984)

    Google Scholar 

  4. N. Nata, H. Rasmussen, Parathyroid hormone, 3’5’AMP, Ca, and renal gluconeogenesis, Proc. Natl. Acad. Sci. USA. 65: 368 – 374 (1970).

    Article  Google Scholar 

  5. F. Glorieux, C.R. Scriver, Loss of a parathyroid hormone-sensitive component of phosphate transport in X-linked hypophosphatemia, Science 175: 997 – 1000 (1972).

    Google Scholar 

  6. M. Drezner, F.A. Nelson, H.E. Lebovitz, Pseudohypoparathyroidism type II: A possible defect in the reception of the cAMP signal, New Engl. J. Med. 289: 1056 – 1060 (1972).

    Article  Google Scholar 

  7. T.H. Steele, Renal rsistance to parathyroid hormone during phosphate deprivation, J. Clin. Invest. 58: 1461–1464 (1976).

    Article  Google Scholar 

  8. D. Aarskog, L. Aksnes, T. Markestad, Effect of parathyroid hormone on cAMP and 1,25-dihydroxyvitamin D formation and renal handling of phosphate in vitamin D-dependent rickets, Pediatr 71: 59 – 63 (1983)

    Google Scholar 

  9. M. Drezner, F.A. Nelson, M. Haussier, H.T. McPherson, H.E. Lebovitz, 1,25-Dihydroxycholecalciferol deficiency: The probable cause of hypocalcemia and metabolic bone disease in pseudohypoparathyroidism. J. Clin. Endocrinol. Metab. 42: 621 – 628 (1976).

    Article  Google Scholar 

  10. H.J. Gloor, J.P. Bonjour, J. Caverzasio, H. Fleisch, Resistance to the phosphaturic and calcemic actions of parathyroid hormone during phosphate depletion. Prevention by 1,25-dihydroxyvitamin D3, J. Clin. Invest. 63: 371 – 377 (1979).

    Article  Google Scholar 

  11. H.J. Rodriquez, H. Villarreal, S. Klahr, E. Slatopolsky, Pseudohypoparathyroidism type II: Resistance of normal renal responsiveness to parathyroid hormone by calcium administration, J. Clin. Endocrinol. Metab. 39: 639 – 701 (1974).

    Article  Google Scholar 

  12. W. Stogmann, J.A. Fischer, Pseudohypoparathyroidism: Disappereance of resistance to parathyroid extract during treatment with vitamin D. Am. J. Med. 59: 140144 (1975).

    Google Scholar 

  13. S.M. Suh, D. Fraser, S.W. Kooh, Pseudohypoparathyroidism responsiveness to parathyroid extract induced by vitamin D2 therapy, J. Clin. Endocrinol. Metab. 30: 609 – 614 (1970)

    Article  Google Scholar 

  14. J.L. Cuche, C.E. Ott, G.R. Marchand, J.A. Diaz-Buro, F.G. Knox, Intrarenal calcium in phosphate handling, Am. J. Physiol. 230: 790 – 796 (1976).

    Google Scholar 

  15. J. Winaver, J. Fragola, T.C. Chen, D.B. Sylk, J.S. Robertson, J.B. Puschett, Potentiation by calcium of the proximal tubular transport effects of parathyroid hormone. Min. Electrol. Metab. 8: 275 – 288 (1982).

    Google Scholar 

  16. C. Evers, H. Murer, R. Kinne, Effect of parathyrin on the transport properties of isolated renal brush border vesicles, Biochem. J. 172:49–56 (1978).

    Google Scholar 

  17. M.R. Hammerman, I.E. Karl, K.A. Hruska, Regulation of canine renal vesicle Pi transport by growth hormone and parathryoid hormone. Biochim. Biophy. Acta 603: 322 – 335 (1980).

    Article  Google Scholar 

  18. L. Chaeng, C.T. Liang, B. Sacktor, In vitro effects of parathyroid hormone on kidney cortical slices: cAMP responses and concomitant inhibition of the Na gradient-dependent uptake of phosphate by brush border membrane vesicles isolated from the renal slices. Endocrinol. Res.Commun. 8(2):97–110 (1981).

    Article  Google Scholar 

  19. T. Takenawa, E. Wada, T. Tsumita, T. Masaki, C.R. Filburn, B. Sacktor, Effect of parathyroid hormone, cyclic AMP and Ca on the phosphorylation of brush border membranes in rabbit kidney. Min. Electrol. Metab. 10: 103 – 112 (1984).

    Google Scholar 

  20. R. Kinne, L.J. Shlatz, E. Kinne-Saffran, I.L. Schwartz, Distribution of membrane-bound cyclic AMP dependent protein kinase in plasma membrane of cells of kidney cortex. J.Membr. Biol. 24: 145 – 159 (1975).

    Google Scholar 

  21. M.R. Hammerman, K.A.Hruska, Cyclic AMP-dependent protein phosphorylation in canine renal brush border membrane vesicles is associated with decreased phosphate transport, J. Biol. Chem. 257: 992 – 999 (1982).

    Google Scholar 

  22. M.R. Hammerman, V.A. Hansen, J.J. Morrisey, Cyclic AMP-dependent protein phosphorylation and dephosphorylation alter phosphate transport in canine renal brush border vesicles, Biochim. Biophy. Acta 755: 10 – 16 (1983).

    Article  Google Scholar 

  23. J. Biber, K. Malmstrom, V. Scalera, H. Murer, Phosphorylation of rat kidney proximal tubular brush border membranes. Role of cAMP dependent protein phosphorylation in the regulation of phosphate transport, Pflugers Arch. 398: 221 – 226 (1983).

    Article  Google Scholar 

  24. S.D. Chung, N. Alavi, D. Livingston, S. Hiller, M. Taub, Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium, J. Cell Biol. 95:118–126 (1982).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Plenum Press, New York

About this chapter

Cite this chapter

Yanagawa, N., Jo, O.D. (1986). Possible Role of Calcium in Parathyroid Hormone Action on Phosphate Transport in Rabbit Renal Proximal Tubules. In: Massry, S.G., Olmer, M., Ritz, E. (eds) Phosphate and Mineral Homeostasis. Advances in Experimental Medicine and Biology, vol 208. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5206-8_13

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-5206-8_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5208-2

  • Online ISBN: 978-1-4684-5206-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics