Abstract
The large forebrain neurons of the substantia innominata (SI) extensively innervate the ipsilateral cerebral cortex (2, 6). In addition, these neurons stain for acetylcholinesterase (7, 9, 13, 18) and lesions of the SI result in 50–80% decreases in cortical choline acetyltransferase (5, 7, 8). These data strongly support the cholinergic makeup of the substantia innominata-cholinergic pathway (SICP). In this report, we summarize our studies of the transynaptic regulation of the SICP, with particular focus on potential direct innervations of the cholinergic cell bodies in the SI. To this end, local injections of defined receptor agonists or antagonists into the SI have been compared with parenteral injections for their actions on cortical cholinergic function.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Costa, E., Panula, P., Thompson, H.K. and Cheney, D.L. (1983): Life Sci. 32: 165–179.
Divac, I. (1975): Brain Res. 93: 385–398.
Haubrich, D.R., Williams, M., Yarbrough, G.G. and Wood, P.L. (1981): Can. J. Physiol. Pharmacol. 59: 1196–1198.
Jhamandas, K., Hron, V. and Sutuk, M. (1975): Can. J. Physiol. Pharmacol. 50: 57–62.
Johnston, M.V., McKinney, M. and Coyle, J.T. (1979): Proc. Natl. Acad. Sci. (USA) 76: 5392–5396.
Jones, E.G., Burton, H., Saper, C.B. and Swanson, L.W. (1976): J. Comp. Neurol. 167: 385–420.
Lehmann, J. and Fibiger, H.C. (1979): Life Sci. 25: 1939–1947.
Lehmann, J., Nagy, J.I., Atmadja, S. and Fibiger, H.C. (1980): Neuroscience 5: 1161–1174.
Mesulam, M.M. and Van Hoesen, G.W. (1976): Brain Res. 109: 15 2157.
Moroni, F., Malthe-Sorenssen,-D., Cheney, D.L. and Costa, E. (1978): Brain Res. 150: 333–341.
Murray, T.F., Blaker, W.D., Cheney, D.L. and Costa, E. (1982): J. Pharmacol. Exp. Ther. 222: 550–554.
Nauta, W.J.H., Smith, G.P., Faull, R.L.M. and Domesick, V.B. (1978): Neuroscience 3: 385–401.
Parent, A., Gravel, S. and Oliver, A. (1979): Adv. Neurol. 24: 1–11.
Perez de la Mora, M., Possan, L.D., Tapin, R., Terun, L., Palacios, R., Fuxe, K., Hkfelt, E. and Ljungdahl, A. (1981): Neuroscience 6: 875–895.
Stone, T.W. and Taylor, D.A. (1980): Exp. Neurol. 70: 556–566.
Szerb, J. (1974): Eur. J. Pharmacol. 29: 192–194.
Walaas, I. and Fonnum, F. (1979): Brain Res. 177: 325–336.
Wenk, H., Bigl, V. and Meyer, U. (1980): Brain Res. Rev. 2: 295316.
Wood, P.L. and Cheney, D.L. (1978): Can. J. Physiol. Pharmacol. 57: 404–411.
Wood, P.L., Peralta, E., Cheney, D.L. and Costa, E. (1979): Neuropharmacology 18: 519–524.
Wood, P.L. and Stotland, L.M. (1980): Neuropharmacology 19:975982..
Wood, P.L. and Rackham, A. (1981): Neurosci. Lett. 23: 75–80.
Wood, P.L., Cheney, D.L. and Costa, E. (1981): Adv. Behay. Biol. 25: 715–722.
Wood, P.L. (1982): Eur. J. Pharmacol. 82: 119–120.
Wood, P.L., Richard, J.W. and Thakur, M. (1982): Life Sci. 31: 2313–2317.
Wood, P.L. and Richard, J.W. (1982): Neuropharmacology 21:969972
Wood, P.L., Stotland, L.M. and Rackham, A. (1984): In Dynamics of Neurotransmitter Function (ed) I. Hanin, Raven Press, New York, pp. 99–107.
Zsilla, G., Cheney, D.L. and Costa, E. (1976): Naunyn-Schmiedebergs Arch. Pharmacol. 294: 251–255.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Wood, P.L., McQuade, P. (1986). Substantia Innominata — Cortical Cholinergic Pathway: Regulatory Afferents. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_98
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5194-8_98
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5196-2
Online ISBN: 978-1-4684-5194-8
eBook Packages: Springer Book Archive