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GABAA VS. GABAB Modulation of Septal-Hippocampal Interconnections

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Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

In rats, intraseptal injection of the GABA receptor agonist muscimol decreases the turnover rate of acetylcholine (TRACh) in the hippocampus in a dose-dependent and bicuculline-reversible manner (15). This is in keeping with the histochemical evidence of a substantial GABAergic innervation of the septal nuclei (11). Furthermore, stimulation of other septal neurotransmitter receptors (e.g., dopamine and beta-endorphin) can decrease the hippocampal TRACh via an activation of GABAergic interneurons (for review see 4). Conversely, some neurotransmitters, such as substance P, modulate the cholinergic activity of this pathway independently from GABAergic mechanisms.

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Author information

Author notes

  1. W. D. Blaker

    Present address: Virginia-Maryland Regional, College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, 24061, USA

Authors and Affiliations

  1. Neuroscience Subdivision, Ciba Geigy Corporation, Summit, New Jersey, 07901, USA

    D. L. Cheney (Director of Neuroscience Research)

  2. Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., 20032, USA

    E. Costa

Authors
  1. W. D. Blaker
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  2. D. L. Cheney
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  3. E. Costa
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Blaker, W.D., Cheney, D.L., Costa, E. (1986). GABAA VS. GABAB Modulation of Septal-Hippocampal Interconnections. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_93

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_93

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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