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Dynamics of Cholinergic Function pp 489–497Cite as

Evoked Release of Acetylcholine at the Motor Endplate

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Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

According to the hypothesis of vesicular release of acetylcholine (ACh) neuromuscular transmission is caused by the simultaneous exocytosis of a large number of synaptic vesicles from the nerve terminals upon the arrival of the action potential (2). At present there is general agreement that nerve stimulation causes a synchronized discharge of ACh packages (quanta), but whether these quanta derive from vesicles is still uncertain. In fact, this has been challenged by results from biochemical experiments, notably those on the electric organ of Torpedo (11, 27).

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Author information

Authors and Affiliations

  1. Department of Biophysics, University College London, Gower Street, London, WC1E 6BT, UK

    R. Miledi

  2. Department of Pharmacology, Sylvius Laboratories, University of Leiden, Wassenaarseweg 72, 2333 AL, Leiden, the Netherlands

    P. C. Molenaar

  3. Medical Biological Laboratory/TNO, P.O. Box 45, 2280 AA, Rijswijk, the Netherlands

    R. L. Polak

Authors
  1. R. Miledi
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  2. P. C. Molenaar
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  3. R. L. Polak
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Miledi, R., Molenaar, P.C., Polak, R.L. (1986). Evoked Release of Acetylcholine at the Motor Endplate. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_47

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_47

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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