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Nicotinic Cholinergic Receptors Labeled with [3H]Acetylcholine in Brain: Characterization, Localization and In Vivo Regulation

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Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

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Abstract

There is evidence from behavioral (21), electrophysiological (15) and pharmacological (23) studies that mammalian brain contains a type of nicotinic cholinergic receptor.(nAChR). The utility of alpha-bungarotoxin (α-BTX) for labeling and measuring nAChR in electroplax, skeletal muscle, and certain peripheral neuronal tissues has encouraged similar investigations in the mammalian central nervous system. Although α-BTX binding sites in brain have been extensively characterized in vitro (for review, see 20), the relationship between these binding sites and nAChR is unclear since nicotinic cholinergic drugs are relatively weak competitors for the α-BTX binding sites (16, 24, 30) and the toxin does not appear to block cholinergic function in various neuronal tissues (6, 18).

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Author notes

  1. R. D. Schwartz

    Present address: Section on Molecular Pharmacology Clinical Neuroscience Branch, National Institute of Mental Health, Building 10, Room 4N214, Bethesda, Maryland, 20205, USA

Authors and Affiliations

  1. Department of Pharmacology, Georgetown University Schools of Medicine and Dentistry, Washington, D.C., 20007, USA

    K. J. Kellar

Authors
  1. R. D. Schwartz
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  2. K. J. Kellar
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Schwartz, R.D., Kellar, K.J. (1986). Nicotinic Cholinergic Receptors Labeled with [3H]Acetylcholine in Brain: Characterization, Localization and In Vivo Regulation. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_45

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_45

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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