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Identification of Putative M1 Muscarinic Receptors Using [3H]Pirenzepine: Characterization of Binding and Autoradiographic Localization in Human Stellate Ganglia

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Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

The advent of selective antimuscarinic drugs such as pirenzepine has led to increased acceptance of the concept of distinct subclasses of muscarinic recegtors. This chapter focuses upon our studies of [3H]pirenzepine ([3H]PZ), which we suggested is an effective ligand for the investigation of putative M1 receptor- effector mechanisms (26–31). Data indicating that [3H]PZ labels putative M1 muscarinic receptors with high affinity is discussed in relation to the growing body of evidence which supports the M1/M2 hypothesis. Emphasis is placed upon our studies of human stellate ganglia. Several relevant reviews have recently appeared in the literature (3, 22, 23, 29).

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Authors and Affiliations

  1. Departments of Pharmacology, Biochemistry, Psychiatry, Pathology, Internal Medicine, and the Arizona Research Laboratories, University of Arizona Health Sciences Center, Tucson, Arizona, 85724, USA

    M. Watson, W. R. Roeske, T. W. Vickroy, K. Akiyama, P. C. Johnson & H. I. Yamamura

  2. Departments of Psychiatry, Anatomy, and Pharmacology, University of Utah School of Medicine, Salt Lake City, Utah, 84132, USA

    J. K. Wamsley

Authors
  1. M. Watson
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  2. W. R. Roeske
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  3. T. W. Vickroy
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  4. K. Akiyama
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  5. J. K. Wamsley
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  6. P. C. Johnson
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  7. H. I. Yamamura
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Watson, M. et al. (1986). Identification of Putative M1 Muscarinic Receptors Using [3H]Pirenzepine: Characterization of Binding and Autoradiographic Localization in Human Stellate Ganglia. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_4

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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