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Cortical Cholinergic Innervation: Distribution and Source in Monkeys

  • Chapter
Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

Cholinergic neurons of the primate basal forebrain, termed the Chl-4 system (18), can be identified by their chromophilia, intensity with which they stain for acetylcholinesterase (AChE) activity, and content of choline acetyltransferase (ChAT)-like immunoreactivity (10, 13, 18, 20). These cholinergic nerve cells are located in the medial septal nucleus (Chl), nucleus of the diagonal band of Broca (dbB) (Ch2), nucleus basalis of Meynert (nbM) (Ch4), and in laminae around the globuspallidus. Anterograde and retrograde transport studies in primates (e.g., 12, 18, 21, 27) and combined tracing and AChE histochemistry (17) show that these neurons project directly to cortex, and suggest that neurons in Chl, Ch2, and Ch4 provide the major source of cholinergic innervation of the amygdala, hippocampus, and neocortex.

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Author information

Authors and Affiliations

  1. Neuropathology Laboratory, Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland, 21205, USA

    R. G. Struble

  2. Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland, 21205, USA

    J. Lehmann & P. G. Antuono

  3. Department of Neurology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland, 21205, USA

    S. J. Mitchell

  4. Division of Comparative Medicine, Neuropathology Laboratory, and Department of Pathology, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland, 21205, USA

    L. C. Cork

  5. Departments of Neuroscience, Pediatrics, Pharmacology and Experimental Therapeutics, and Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland, 21205, USA

    J. T. Coyle

  6. Neuropathology Laboratory, Departments of Pathology, Neurology and Neuroscience, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland, 21205, USA

    D. L. Price

  7. Departments of Neurology and Neuroscience, The Johns Hopkins University School of Medicine, 600 North Wolfe Street, Baltimore, Maryland, 21205, USA

    M. R. Delong

Authors
  1. R. G. Struble
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  2. J. Lehmann
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  4. L. C. Cork
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  5. J. T. Coyle
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  6. D. L. Price
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  7. M. R. Delong
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  8. P. G. Antuono
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Struble, R.G. et al. (1986). Cortical Cholinergic Innervation: Distribution and Source in Monkeys. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_3

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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