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Sympathetic Ingrowth: A Result of Cholinergic Nerve Injury in the Adult Mammalian Brain

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Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

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Abstract

The brain is capable of dramatic and vigorous responses to injury. We have been studying one such rearrangement, sympathetic ingrowth, which takes place in the adult rat brain after injury to certain central cholinergic pathways. The purpose of this chapter is to describe sympathetic ingrowth, its regulation and function. Although sympathetic ingrowth appears to be an unusual and perhaps anomalous form of neuronal plasticity, its study has led to a better understanding of the molecular mechanisms that probably underlie the regulation of other neuronal rearrangements. The ability to regulate neuronal rearrangements such as sympathetic ingrowth is likely to lead to the development of pharmacological agents that may be useful to patients with brain injury, stroke or dementia.

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Author information

Authors and Affiliations

  1. Neurology Research Laboratory, V.A. Medical Center, Durham, North Carolina, 27705, USA

    J. N. Davis

  2. Departments of Medicine and Pharmacology, Duke University Medical Center, Durham, North Carolina, 27705, USA

    J. N. Davis

Authors
  1. J. N. Davis
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Davis, J.N. (1986). Sympathetic Ingrowth: A Result of Cholinergic Nerve Injury in the Adult Mammalian Brain. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_23

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_23

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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