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Basal Forebrain Cholinergic Systems in Primate Brain: Anatomical Organization and Role in the Pathology of Aging and Dementia

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Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

Over the past several years, there have been substantial advances in our understanding of cholinergic systems in the primate central nervous system. Cholinergic neurons in the medial septum, diagonal band of Broca (dbB), and nucleus basalis of Meynert (nbM) provide the major cholinergic innervation to the amygdala, hippocampus, and neocortex. These cholinergic cell groups, recently termed the Chl-4 system (26), are affected in Alzheimer’s disease (AD) and related disorders. In this review, we first discuss: the anatomical organization of the Chl-4 system; evidence implicating this system in the pathology of AD and related disorders; and hypothetical models by which dysfunction and, eventually, death of these cells may account for some of the neurochemical/neuropathological changes observed in the brains of individuals with AD and related dementias.

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Author information

Authors and Affiliations

  1. Neuropathology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    D. L. Price, C. A. Kitt, J. C. Hedreen, P. J. Whitehouse, R. G. Struble, L. C. Cork, L. C. Walker & W. C. Mobley

  2. Division of Neuroscience, City of Hope Research Institute, Duarte, California, USA

    G. D. Crawford & P. M. Salvaterra

  3. Department of Pathology, University of Chicago, Chicago, Illinois, USA

    B. H. Wainer

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  1. D. L. Price
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  2. C. A. Kitt
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  8. W. C. Mobley
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  9. G. D. Crawford
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Price, D.L. et al. (1986). Basal Forebrain Cholinergic Systems in Primate Brain: Anatomical Organization and Role in the Pathology of Aging and Dementia. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_21

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

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