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Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in Alzheimer’s Disease

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Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

Abstract

The literature concerning age effects on cholinergic neurochemical parameters, in the brain presents a heterogeneous picture, both within and among species. Whereas some studies of human postmortem material have demonstrated age-dependent declines in choline acetyltransferase (ChAT) activity in various brain regions (5, 12, 19), others have revealed no ChAT losses in some of the same regions (5, 10, 12, 19, 28). In brain regions from C57BL/6J and A/J mice, we have observed age-dependent increases in ChAT (26); whereas, other studies have revealed no changes or decreases in the brains of C57BL/6J mice (23, 25), other mouse strains (24), and rats (2, 23, 25).

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References

  1. Ben-Barak, Y., Gazit, H. and Dudai, Y. (1980): Brain Res. 194: 249–253.

    Article  Google Scholar 

  2. Briggs, R.S., Petersen, M.M. and Cook, P.J. (1982): Neurobiol. Aging 3: 259–261.

    Article  Google Scholar 

  3. Bull, G. AndOderfeld-Nowak, B. (1971): J. Neurochem. 19: 935–947.

    Article  Google Scholar 

  4. Coleman, G.L., Barthold, L.S., Osbaldiston, G.W., Foster, S.J. and Jones, A.M. (1977): J. Gerontol. 32: 258–278.

    Google Scholar 

  5. Davies, P. (1979): Brain Res. 171: 319–327.

    Article  Google Scholar 

  6. Davies, P. and Verth, A.H. (1977): Brain Res. 138: 385–392.

    Article  Google Scholar 

  7. Freund, G. (1980): Life Sci. 26: 371–375.

    Article  Google Scholar 

  8. Ikeda, S.R., Aronstam, R.S. and Eldefrawi, M.E. (1980): Neuropharmacol. 19: 575–585.

    Article  Google Scholar 

  9. Lowry, O.H., Rosebrough, N.J., Farr, A.L. and Randall, R.J. (1951): J. Biol. Chem. 193: 265–275.

    Google Scholar 

  10. MacKay, N.V., Davies, P., Dewar, A.J., and Yates, C.M. (1978): J. Neurochem. 30: 827–839.

    Article  Google Scholar 

  11. Maker, H.S., Lehrer, G.M., Siliders, D.J. and Weiss, C. (1973): Prog. Brain Res. 40: 293–307.

    Article  Google Scholar 

  12. McGeer, E.G. and McGeer, P.L. (1976): In Neurobiology of Aging (eds) R.D. Terry and S. Gershon, Raven Press, New York pp. 389–403.

    Google Scholar 

  13. McKinney, M. and Coyle, J.T. (1982): J. Neurosci. 2: 97–105.

    Google Scholar 

  14. Miller, R.G., Jr. (1966): Simultaneous Statistical Inference, McGraw-Hill, New York, pp. 67–70:

    Google Scholar 

  15. Morin, A.M. and Wasterlain, C.G. (1980): Neurochem. Res. 5: 301–308.

    Article  Google Scholar 

  16. Nordberg, A., Larsson, C., Adolfsson, R., Alafuzoff, I. and Winblad, B. (1983): J. Neural Transmission 56: 13–19.

    Article  Google Scholar 

  17. Nordberg, A. and Winblad, B. (1981): Life Sci. 29: 1937–1944.

    Article  Google Scholar 

  18. Pedhazur, E.J. (1982): Multiple Regression in Behavioral Research, CBS College Publishing, New York, p. 103.

    Google Scholar 

  19. Perry, E.K., Gibson, P.H., Blessed, G., Perry, R.H. and Tomlinson, B.E. (1977): J. Neurol. Sci. 34: 257–265.

    Article  Google Scholar 

  20. Russell, E.S. (1966): In Biology of the Laboratory Mouse (ed) E.L. Green, McGraw-Hill, New York, pp. 511–519.

    Google Scholar 

  21. Simon, R.G. and Klein, W.L. (1979): Proc. Natl. Acad. Sci., U.S.A. 76: 4141–4145.

    Article  Google Scholar 

  22. Snyder, S.H. (1976): In Basic Neurochemistry (eds) G. Siegel, R. Albers, R. Katzman and B. Agranoff, Little, Brown and Company, Boston, p. 203–217.

    Google Scholar 

  23. Strong, R., Hicks, P., Hsu, L., Bartus, R.T. and Enna, S.J. (1980): Neurobiol. Aging 1: 59–63.

    Article  Google Scholar 

  24. Unsworth, B.R., Fleming, L.H., and Caron, P.C. (1980): Mech. Aging Develop. 13: 2

    Article  Google Scholar 

  25. Vijayan, V.K. (1977): Exp Neurol. 12: 7–11.

    Google Scholar 

  26. Waller, S.B., Ingram, D.K., Reynolds, M.A. and London, E.D. (1983): J. Neurochem. 41: 1421–1428.

    Article  Google Scholar 

  27. Waller, S.B. and London, E.D. (1983): Exp. Gerontol. 18: 419–425.

    Article  Google Scholar 

  28. White, P., Goodhardt, M.J., Keet, J.P., Hiley, C.R., Caraso, L.H., Williams, J.E.J. and Bowen, D.M. (1977): Lancet 1: 668–671.

    Article  Google Scholar 

  29. Yamamura, H.I. and Snyder, S.H. (1974): Proc. Nat. Acad. Sci. U.S.A. 71: 1725–1729.

    Article  Google Scholar 

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Authors and Affiliations

  1. Addiction Research Center National Institute on Drug Abuse, c/o Francis Scott Key Medical Center, Baltimore, Maryland, 21224, USA

    E. D. London

  2. Gerontology Research Center, National Institute on Aging, c/o Francis Scott Key Medical Center, Baltimore, Maryland, 21224, USA

    E. D. London & S. B. Waller

Authors
  1. E. D. London
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  2. S. B. Waller
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Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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London, E.D., Waller, S.B. (1986). Relationships between Choline Acetyltransferase and Muscarinic Binding in Aging Rodent Brain and in Alzheimer’s Disease. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_19

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_19

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

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