Abstract
Aged humans show a pattern of cognitive impairments in which recent memory deficits are superimposed on a more global cognitive deterioration which typically includes deficits in attention, decreased processing speed, cognitive rigidity and interference from previous associations (1, 10). Research extending over the last decade has shown that this pattern of impairments, particularly the decline in recent memory, is a common characteristic of aging in many mammalian species including humans, nonhuman primates, rats and mice (2, 3, 17, 22). In humans these impairments are exacerbated by senile dementia of the Alzheimer type (SDAT), which affects 10% of all persons over 65 years of age and 30% of those over 85. Although the neurochemical changes responsible for the cognitive loss in aged or demented subjects are not completely understood, extensive evidence (5, 9, 11) suggests that a dysfunction of central cholinergic transmission plays an important role.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Albert, M.S. and Kaplan, E. (1980): In: New Directions in Memory and Aging (eds) L.W. Poon, J.L. Fozard, L.S. Cermak, D. Arenberg and L.W. Thompson, Erlbaum, Hillsdale, New Jersey, pp. 403–432.
Bartus, R.T. (1979): In: Aging: Sensory Systems and Communi¬cation in the Elderly, Vol. 10 (eds) J.M. Ordy and K. Brizzee, Raven Press, New York, pp. 85–114.
Bartus, R.T. (1980): In: Aging in the 1980’s: Psychological Issues (ed) L.W. Poon, American Psychological Association, Wash¬ington, D.C., pp. 163–180.
Bartus, R.T., Dean, R.L. and Beer, B. (1983): Psychopharma¬cology Bulletin 19: 168–184.
Bartus, R.T., Dean, R.L., Beer, B. and Lippa, A.S. (1982): Science 217: 408–417.
Bartus, R.T., Dean, R.L., Flicker, C., Pontecorvo, M.J., Figu¬eiredo, J.C. and Fisher, S.K.: In Preparation.
Christie, J.E. (1982): In: Aging: Alzheimer’s Disease: A Report of Progress in Research, Vol. 19 (eds) S. Corkin, K.L. Davis, J.H. Growdon, E. Usdin and R.J. Wurtman, Raven Press, New York, pp. 413–420.
Corkin, S., Davis, K.L., Growdon, J.H., Usdin, E. and Wurtman, R.J. (1982): (eds) Aging: Alzheimer’s Disease: A report of Progress in Research, Vol. 19, Raven Press, New York.
Coyle, J.T., Price, D.L. and DeLong, M.R. (1983): Science 219: 1184–1190.
Craik, F.I.M. (1977): In: Handbook of Psychology of Aging (eds) J.E. Birren and K.W. Schaie, Van Nostrand Reinhold, New York, pp. 384–419.
Davies, P. (1981): In: Strategies for the Development of an Effective Treatment for Senile Dementia (eds) T. Crook and S. Gershon, Mark Powley Associates, New Canaan, Connecticut, pp. 19–34.
Dean, R.L., Beer, B. and Bartus, R.T. (1982): Neuroscience Abstracts 8: 87. 16.
Drachman, D.A. (1977): Neurology 27: 783–790.
Drachman, D.A. and Leavitt, J. (1974): Archives of Neurology 30: 113–121.
Ferris, S.H., Reisberg, B. and Gershon, S. (1980): In: Aging in the 1980’s: Psychological Issues(ed) L.W. Poon, American Psychological Association, Washington, D.C., pp. 212–220.
Flicker, C., Dean, R.L., Watkins, D.L., Fisher, S.K. and Bartus, R.T. (1983): Pharmacology, Biochemistry and Behavior 18: 973–981.
Flicker, C., Bartus, R.T., Ferris, S.F. and Crook, T.: In prep¬aration.
Friedman, E., Lerer, B. and Kuster, J. (1983): Pharmacology, Biochemistry and Behavior 19: 309–312.
Gorry, J.D. (1963): Acta Anatomica 55: 51–104.
Gray, J.A. and McNaughton, N. (1983): Neuroscience and Bio¬behavioral Reviews 7: 119–188.
Guldin, W.O. and Markovitch, H.J. (1982): Journal of Neuro¬science Methods 5: 83–93.
Kubanis, P. and Zornetzer, S.F. (1981): Behavioral and Neural Biology 31: 115–172.
Lerer, G., Gamzu, E. and Friedman, E.: This book.
LoConte, G., Bartolini, L., Casamenti, F., Marconcini-Pepeu, I. and Pepeu, G. (1982): Pharmacology Biochemistry and Behavior 17: 933–937.
Perry, E.K., Tomlinson, B.E., Blessed, G., Bergmann, K., Gibson, P.H. and Perry, R.H. (1978): British Medical Journal 2: 1457–1459.
Price, D.L., Kitt, C.A., Hedreen,J.C., Whitehouse, P.J., Struble, R.G., Cork, L.C., Walker, L.C., Mobley, W.C.,Salvaterra, P.M. and Wainer, B.H.: This book.
Schwarcz, R., Hokfelt, T., Fuxe, K. Jonsson, G., Goldstein, M. and Terenius, L. (1979): Experimental Brain Research 37: 199–216.
Wilcock, G.K., Esiri, M.M., Bowen, D.M. and Smith, C.C.T. (1982): Journal of the Neurological Sciences 57: 407–417.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Pontecorvo, M.J., Flicker, C., Bartus, R.T. (1986). Cholinergic Dysfunction and Memory; Implications for the Development of Animal Models of Aging and Dementia. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_18
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5194-8_18
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5196-2
Online ISBN: 978-1-4684-5194-8
eBook Packages: Springer Book Archive