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The Aging of Cholinergic Synapses: Ontogenesis of Cholinergic Receptors

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Dynamics of Cholinergic Function

Part of the book series: Advances in Behavioral Biology ((ABBI,volume 30))

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Abstract

Cholinergic synapses in brain undergo dynamic changes during development, maturation and aging. During the life span we can assume that there is a continuous interregulation between presynaptic and postsynaptic activity. In recent years several investigators have shown for example that both muscarine- and nicotine-like receptor binding sites in brain can be modulated by a continuous drug treatment (13, 23, 31, 32, 34, 37). Signs for a compensatory “upregulating” mechanism for muscarinic binding sites have been reported in pathological states such as dementia of Alzheimer type (29) and Parkinson’s Disease (35).

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Author information

Authors and Affiliations

  1. Department of Pharmacology, University of Uppsala, Box 573, S-751 23, Uppsala, Sweden

    A. Nordberg

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  1. A. Nordberg
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Editor information

Editors and Affiliations

  1. Loyola University Stritch School of Medicine, Chicago, Illinois, USA

    Israel Hanin Ph.D.

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© 1986 Plenum Press, New York

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Nordberg, A. (1986). The Aging of Cholinergic Synapses: Ontogenesis of Cholinergic Receptors. In: Hanin, I. (eds) Dynamics of Cholinergic Function. Advances in Behavioral Biology, vol 30. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5194-8_15

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  • DOI: https://doi.org/10.1007/978-1-4684-5194-8_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5196-2

  • Online ISBN: 978-1-4684-5194-8

  • eBook Packages: Springer Book Archive

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