Enantiomeric Analogues of SCH 23390 as New Probes for Behavioral Interactions between D1 and D2 Dopaminergic Function
The recent identification of the first selective D1 dopamine (DA) receptor antagonist, the 1-phenyl-1H-3-benzazepine derivative SCH 23390 (Iorio et al., 1983; Hyttel, 1983; Cross, et al., 1983; O’Boyle and Waddington, 1984a), was an event eagerly awaited as the final piece in a psychopharma-cological jigsaw that had for some time remained incomplete. The now widely accepted designation of D1 and D2 subtypes of DA receptor (Kebabian and Calne, 1979; Seeman, 1980; Leff and Creese, 1983; Waddington, et al., 1986) arose in the absence of selective D1 antagonists. Therefore, such a drug was clearly required to substantiate any functional distinctions between these subtypes, in the classical manner of previous schemes for heterogeneity in non-DAergic receptor populations.
KeywordsDopamine Receptor Dopamine Agonist Stereotyped Behavior Dopamine Antagonist Agonist Apomorphine
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