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The Multiplicity of the D1 Dopamine Receptor

  • Chapter
Neurobiology of Central D1-Dopamine Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 204))

Abstract

Dopaminergic neurotransmission is known to modulate a variety of behaviors, including ambulation (Ungerstedt and Arbuthnott, 1970; Pijnenburg et al., 1976), stereotyped behaviors (Creese and Iversen, 1973), self-stimulation (Phillips and Fibiger, 1973), conditioned avoidance responding (Seiden and Carlsson, 1963), stimulus control (Ho and Huang, 1975), and feeding and drinking (Ungerstedt, 1971; Fitzsimons and Setler, 1975). It is not surprising, therefore, that drugs which are believed to act primarily as dopamine receptor agonists or antagonists have important clinical utility. Our work has sought to address two questions of some neuropharmacological importance. First, what is the nature of mechanisms by which dopamine initiates many of these psychopharmacological effects, and second, is it possible to design highly specific drugs targeted only at a selected subpopulation of dopamine receptors?

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Authors and Affiliations

  1. Biological Sciences Research Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27514, USA

    Richard B. Mailman, David W. Schulz & Mark H. Lewis

  2. Departments of Psychiatry and Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27514, USA

    Richard B. Mailman

  3. Neurobiology Curriculum, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27514, USA

    Richard B. Mailman & David W. Schulz

  4. Department of Medicinal Chemistry, University of North Carolina School of Medicine, Chapel Hill, North Carolina, 27514, USA

    Steven Wyrick

  5. Department of Psychiatry, Duke University Medical Center, Durham, N.C., 27710, USA

    Clinton D. Kilts

  6. Reiksuniversiteit, Groningen, Netherlands

    Hans Rollema

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  1. Richard B. Mailman
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  2. David W. Schulz
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  3. Clinton D. Kilts
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  4. Mark H. Lewis
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  5. Hans Rollema
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  6. Steven Wyrick
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Editors and Affiliations

  1. University of North Carolina at Chapel Hill, Chapel Hill, North Caronila, USA

    George R. Breese

  2. University of California, San Diego, La Jolla, Carlifornia, USA

    Ian Creese

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© 1986 Plenum Press, New York

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Mailman, R.B., Schulz, D.W., Kilts, C.D., Lewis, M.H., Rollema, H., Wyrick, S. (1986). The Multiplicity of the D1 Dopamine Receptor. In: Breese, G.R., Creese, I. (eds) Neurobiology of Central D1-Dopamine Receptors. Advances in Experimental Medicine and Biology, vol 204. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5191-7_4

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  • DOI: https://doi.org/10.1007/978-1-4684-5191-7_4

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