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Neurobiology of D1 Dopamine Receptors after Neonatal-6-OHDA Treatment: Relevance to Lesch-Nyhan Disease

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Neurobiology of Central D1-Dopamine Receptors

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 204))

Abstract

Central administration of 6-hydroxydopamine (6-OHDA) to adult or neonatal rats destroys dopamine-containing neurons, produces a variety of behavioral deficits (Breese et al., 1973; Smith et al., 1973) and enhances behavioral responses to dopamine agonists (Ungerstedt, 1971; Schoenfeld and Uretsky, 1972; Hollister et al., 1974; 1979; Setler et al. 1978; Kilts et al. 1979). In spite of the common biochemical deficiency observed in neonatally and adult-lesioned rats, Breese et al. (1984 a,b) reported that certain behavioral responses to L-DOPA or apomorphine in adult-6-OHDA-treated rats (Breese et al., 1970) differ from those observed in rats lesioned as neonates and tested with dopamine agonists as adults (Breese et al., 1972; Smith et al., 1973). For example, neonatally 6-OHDA-lesioned rats exhibit self-mutilation behavior (SMB) after treatment with dopamine agonists which do not elicit this response in adult-6-OHDA treated rats (Breese et al., 1984b).

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Authors and Affiliations

  1. Biological Sciences Research Center and the Mental Health Clinical Research Center, University of North Carolina School of Medicine, Chapel Hill, N.C., 27514, USA

    George R. Breese, Robert A. Mueller, T. Celeste Napier & Gary E. Duncan

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  1. George R. Breese
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  2. Robert A. Mueller
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  3. T. Celeste Napier
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  4. Gary E. Duncan
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Editors and Affiliations

  1. University of North Carolina at Chapel Hill, Chapel Hill, North Caronila, USA

    George R. Breese

  2. University of California, San Diego, La Jolla, Carlifornia, USA

    Ian Creese

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© 1986 Plenum Press, New York

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Breese, G.R., Mueller, R.A., Napier, T.C., Duncan, G.E. (1986). Neurobiology of D1 Dopamine Receptors after Neonatal-6-OHDA Treatment: Relevance to Lesch-Nyhan Disease. In: Breese, G.R., Creese, I. (eds) Neurobiology of Central D1-Dopamine Receptors. Advances in Experimental Medicine and Biology, vol 204. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5191-7_13

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  • DOI: https://doi.org/10.1007/978-1-4684-5191-7_13

  • Publisher Name: Springer, Boston, MA

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