The Pathophysiological Functions Mediated by D1 Dopamine Receptors
Pharmacological and biochemical studies have established the presence of at least two types of central dopamine (DA) receptors. The D1 DA receptors are positively linked to the DA sensitive adenylate cyclase system, whereas the D2 DA receptors are probably negatively linked. The D2 DA receptors have been generally recognized as mediating the action of antipsychotic drugs as well as a variety of behaviors such as rotation and stereotypy. However, until recently, the D1 DA receptor was regarded as a receptor whose function is unknown and awaiting future discovery. The availability of selective D1 DA agonists (e.g. SKF 38393) and of D1 DA antagonists (e.g. SCH 23390) has made it possible to determine some behavioral effects which are associated with D1 or with both D1 and D2 DA receptors. In this presentation we will describe some behavioral responses which might be mediated by D1 and/or by both D1 and D2 DA receptors, and we will discuss their clinical relevance.
KeywordsTyrosine Hydroxylase Receptor Supersensitivity Salvage Enzyme Muscarinic Antagonist Scopolamine Dopaminergic Neuronal Function
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