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Interaction of D1 and D2 Dopamine Receptors in the Expression of Dopamine Agonist Induced Behaviors

  • Allen R. Braun
  • Paolo Barone
  • Thomas N. Chase
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 204)

Abstract

The study of behaviors induced by centrally acting dopaminergic agents is a classical means of investigating the pharmacology of the dopamine system and the pathophysiology of human neuropsychiatric diseases for which these behaviors serve as animal models. Observation and quantification of stereotypic and nonstereotypic behaviors has been a standard research protocol since the earliest work on the central activity of amphetamine and related agents (Randrup and Munkvad, 1967; Kelly and Iversen, 1975). Quantification of rotational behavior in lesioned rats (Ungerstedt and Arbuthnott, 1970) has more recently become an established means of investigating the activity of dopaminergic agents within the CNS. The compartmentalization of dopamine receptors on the basis of their ability to stimulate (D1 receptors) or not stimulate (D2 receptors) adenylate cyclase (Kebabian and Calne, 1979) and the introduction of agents selective for these receptor subtypes have provided the means with which to extend the classical behavioral observations and to utilize these techniques to more comprehensively characterize the pharmacology of the central dopamine system.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Allen R. Braun
    • 1
  • Paolo Barone
    • 1
  • Thomas N. Chase
    • 1
  1. 1.Experimental Therapeutics BranchNational Institute of Neurological and Communicative Disorders and Stroke National Institutes of HealthBethesdaUSA

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