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Effect of Norepinephrine and Angiotensin II on Intrarenal Oxygen Availability

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Oxygen Transport to Tissue VIII

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 200))

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Abstract

Oxygen availability (O2a) in the cortex, outer medulla, inner medulla, and papilla of the left kidney was measured in 12 unanesthetized rabbits implanted with O2 sensitive electrodes. Each was injected with a single i.v. bolus of either norepinephrine (NE) or angiotensin II (AII) in equipressor doses, and intrarenal O2a was continuously recorded. The NE response consisted of parallel and proportional intrarenal O2a decreases and overshoots in all zones; AII response consisted of progressively smaller O2a decreases from outer to inner zones during maximum response and smaller increases during maximum overshoot. These response differences may be important under various physiologic or pathologic conditions.

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Author information

Authors and Affiliations

  1. Department of Pediatrics, University of Miami School of Medicine, Miami, Florida, 33101, USA

    Rex Baker, Rex Baker, Anthony V. Beran & Jose Strauss

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  1. Rex Baker
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  2. Anthony V. Beran
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  3. Jose Strauss
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Editors and Affiliations

  1. North Carolina State University, Raleigh, North Carolina, USA

    Ian S. Longmuir

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© 1986 Plenum Press, New York

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Baker, R., Beran, A.V., Strauss, J. (1986). Effect of Norepinephrine and Angiotensin II on Intrarenal Oxygen Availability. In: Longmuir, I.S. (eds) Oxygen Transport to Tissue VIII. Advances in Experimental Medicine and Biology, vol 200. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5188-7_49

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  • DOI: https://doi.org/10.1007/978-1-4684-5188-7_49

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5190-0

  • Online ISBN: 978-1-4684-5188-7

  • eBook Packages: Springer Book Archive

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