Abstract
We have measured sinus nerve discharge, tissue PO2 and oxygen consumption (vO2) in cat carotid bodies under different experimental conditions using our recessed oxygen microelectrode. Our results indicate that the change in chemoreceptor activity with oxygen disappearance following blood flow occlusion can be related to a two cytochrome model for oxygen consumption as previously proposed by Mills and Jöbsis (1972).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Acker, H. and Lubbers, D. W. The kinetics of local tissue PO2 decrease after perfusion stop within the carotid body of the cat in vivo and in vitro. Pflugers Arch. 369: 135–140, 1977.
Buerk, D. G. and Longmuir, I. S. Evidence for nonclassical respiratory activity from oxygen gradient measurements in tissue slices. Microvas. Res. 13: 345–353, 1977.
uerk, D. G. and Saidel, G. M. Local kinetics of oxygen metabolism in brain and liver tissue slices. Microvas. Res. 16: 391–405, 1978.
Buerk, D. G. and Goldstick, T. K. Multiple oxidase model for oxygen consumption in tissue. Fed. Proc. (abstract) 37: 598, 1978.
Buerk, D. G., Nair, P. K., Bridges, E. W. and Hanley, T. R.
Interpretation of oxygen disappearance curves measured in blood prefused tissues. This Symposium.
Eyzaguirre, C., Fitzgerald, R. S., Lahiri, S. and Zapata, P. Arterial chemoreceptors. In: Handbook of Physiology Section 2: The Cardiovascular System Volume III: Peripheral Circulation and Organ Blood Flow, Part 2. American Physiological Society, Bethesda, MD. Ch. 16, p. 557–621, 1983.
Jones, D. P. Effect of mitochondrial clustering on 02 supply in hepatocytes. Am. J. Physiol. 247: C83 - C89, 1984.
Mills, E. and Jöbsis, F. F. Mitochondrial respiratory chain of carotid
body and chemoreceptor response to changes in oxygen tension. J. Neurophysiol. 35: 405–428, 1972.
Nair, P., Spande, J. I., and Whalen, W. J. Marking the tip location of P02 microelectrode or glass micropipettes. J. Appl. Physiol. 49: 916–918, 1980.
Reneau, D. D. and Halsey, Jr., J. H. Interpretation of oxygen disappearance rates in brain cortex following total ischaemia. In: Oxygen Transport to Tissue–II, Silver et al. (eds.), Plenum Press, N.Y., pp. 189–198, 1978.
Whalen, W. J., Riley, J. and Nair, P. A microelectrode for measuring intracellular P02. J. Appl. Physiol. 23: 789–801, 1967.
Whalen, W. J., and Nair, P. Factors affecting 02 consumption of the cat carotid body. In: Chemoreception in the Carotid Body, Acker et al. (eds.), Springer-Verlag, Berlin, West Germany, pp. 233–239, 1977.
Whalen, W. J., Nair, P., Sidebotham, T., Spande, J. and Lacerna, M. Cat carotid body: oxygen consumption and other parameters. J. Appl. Physiol_. 50: 129–133, 1981.
Whalen, W. J., and Nair, P. Oxidative metabolism and tissue PO2 of the carotid body. In: Physiology of the Peripheral Arterial Chemoreceptors, Acker and O’Regan (eds.), Elsevier, N.Y., Ch. 6, pp. 116–132, 1983.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Nair, P.K., Buerk, D.G., Whalen, W.J., Schubert, R.W. (1986). Two Cytochrome Oxygen Consumption Model and Mechanism for Carotid Body Chemoreception. In: Longmuir, I.S. (eds) Oxygen Transport to Tissue VIII. Advances in Experimental Medicine and Biology, vol 200. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5188-7_36
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5188-7_36
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5190-0
Online ISBN: 978-1-4684-5188-7
eBook Packages: Springer Book Archive