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Tumor-Associated Glycolipid Markers: Possible Targets for Drug and Immuno-Toxin Delivery

  • Chapter
Targeting of Drugs With Synthetic Systems

Part of the book series: NATO ASI Series ((NSSA,volume 113))

Abstract

In order to achieve effective targeting of antibody-drug conjugates to specific types of cells, a comprehensive understanding of the chemical, physical, and dynamic properties of cell surface structures is essential. Glycosphingolipids (briefly, glycolipids), as discussed here, are potentially useful to achieve effective targeting for the following reasons: (i) They are an integral part of the lipid bilayer, and the majority are assumed to be inserted at the outer leaflet of the plasma membrane; (ii) their structure and organization in membranes differ from one type of cell to another and constitute characteristic cell surface specificity of each type of cell? and (iii) they may be more readily internalized than other membrane components, since receptor carbohydrates are directly inserted in membranes.

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Authors and Affiliations

  1. Program of Biochemical Oncology and Membrane Research Fred Hutchinson Cancer Research Center, Departments of Pathobiology, Microbiology, and Immunology, University of Washington, Seattle, WA, 98104, USA

    Sen-itiroh Hakomori

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  1. Sen-itiroh Hakomori
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Editors and Affiliations

  1. Royal Free Hospital School of Medicine, London, England

    Gregory Gregoriadis  & Judith Senior  & 

  2. Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

    George Poste

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© 1986 Plenum Press, New York

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Hakomori, Si. (1986). Tumor-Associated Glycolipid Markers: Possible Targets for Drug and Immuno-Toxin Delivery. In: Gregoriadis, G., Senior, J., Poste, G. (eds) Targeting of Drugs With Synthetic Systems. NATO ASI Series, vol 113. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5185-6_3

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  • DOI: https://doi.org/10.1007/978-1-4684-5185-6_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5187-0

  • Online ISBN: 978-1-4684-5185-6

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