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Polymers as Matrices for Drug Release

  • Chapter
Targeting of Drugs With Synthetic Systems

Part of the book series: NATO ASI Series ((NSSA,volume 113))

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Abstract

The pharmaceutical applications of synthetic polymers may be broadly divided into two main sections: the physical incorporation of active molecules into a polymeric matrix, from which they may be subsequently released either by diffusion processes, or by erosion and the synthesis of pharmacologically active polymers. Pharmacologically active polymers may be classified as follows:

  1. 1.

    Polymers which are pharmacologically active per se, their activity dependant on macromolecularity. The corresponding monomers, or non-macro-molecular models, are inactive.

  2. 2.

    Polymers whose activity depends on moieties structurally related to well known non-macromolecular drugs, linked to the macromolecular backbone with covalent bonds which are not expected to be cleaved in order to exert activity.

  3. 3.

    Polymers which are able to give rise to non-macromolecular active substances after administration. These may be further divided into two main categories: a) Polymers in which residues of active molecules are constituents of the main backbone. Consequently, the active molecules are released by degradation of the whole macromolecule; b) Polymers in which residues of active molecules are linked as side substituents to a polymeric or oligomeric structure with covalent bonds cleavable in body environments. The release of active molecules does not necessarily involve a degradation of the whole produce, which may or may not take place as a separate process.

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Author information

Authors and Affiliations

  1. Facolta d’Ingegneria, Universita di Brescia, Viale Europa n. 39, 25060, Brescia, Italy

    Paolo Ferruti

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  1. Paolo Ferruti
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Editors and Affiliations

  1. Royal Free Hospital School of Medicine, London, England

    Gregory Gregoriadis  & Judith Senior  & 

  2. Smith Kline & French Laboratories, Philadelphia, Pennsylvania, USA

    George Poste

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© 1986 Plenum Press, New York

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Ferruti, P. (1986). Polymers as Matrices for Drug Release. In: Gregoriadis, G., Senior, J., Poste, G. (eds) Targeting of Drugs With Synthetic Systems. NATO ASI Series, vol 113. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5185-6_12

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  • DOI: https://doi.org/10.1007/978-1-4684-5185-6_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5187-0

  • Online ISBN: 978-1-4684-5185-6

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