Abstract
The synthetic polyribonucleotide, poly [r(G-C)], has been shown to undergo a transition from the right handed A-form to a left-handed Z-conformation.1 This is the first major conformational change found in double-stranded RNA.2 Therefore it is important to corroborate this observation, to characterize the conditions that produce Z-RNA, and to determine some of the properties of this novel left-handed structure. This article is a summary of our results in this area.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
K. Hall, P. Cruz, I. Tinoco, Jr., T. M. Jovin, and J. H., van de Sande, Nature 311, 584–586 (1984).
W. Saenger, Principles of Nucleic Acid Structure, Springer-Verlag, New York, Chapter 9, 1984.
K. Hall, P. Cruz, and M. J. Chamberlin, Arch. Biochem. Biophys. 236, 47–51 (1985).
D. J. Patel, S. A. Kozlowski, A. Nordheim and A. Rich, Proc. Natl. Acad. Sci., U. S. A. 79, 1413–1417 (1982).
T. M. Jovin, J. H. van de Sande, D. A. Zarling, D. J. Arndt-Jovin, F. Eckstein, H. H. Fuldner, C. Greider, I. Grieger, R. Hamori, B. Kalisch, L. P. Mclntosh and M. Robert-Nicoud and L. B. Clark, Cold Spring Harbor Symp. Quant Biol. 47, 143–154 (1983).
J. H. Riazance, W. A. Baase, W. C. Johnson, Jr., K. Hall, P. Cruz, I. Tinoco, Jr., Nucleic Acids Res., 13, 4983–4989 (1985).
A. Williams, Jr., C. Cheong, I. Tinoco, Jr., unpublished results.
I. Tinoco, Jr., C. Bustamante and M. F. Maestre, Ann. Rev. Biophys. Bioeng. 9, 107–141 (1980).
V. Rizzo and J. A. Schellman, Biopolymers, 23, 435–470 (1984).
L. B. Clark, J. Am. Chem. Soc. 99, 3934–3938 (1977).
T. J. Thamann, R. C. Lord, A. H.-J. Wang and A. Rich, Nucleic Acids Res. 9, 5443–5457 (1981).
M. Behe and G. Felsenfeld, Proc. Natl. Acad. Sci., U. S. A. 78, 1619–1623 (1981).
R. V. Gessner, G. J. Quigley, A. H.-J. Wang, G. A. van de Marel, J. H. van Boom and A. Rich, Biochemistry 24, 237–240 (1985).
A. Moller, A. Nordheim, S. A. Kozlowski, D. J. Patel and A. Rich, Biochemistry 23, 54–62 (1984).
B. G. Feurstein, L. J. Marton, M. A. Keniry, D. L. Wade and R. H. Shafer, Nucleic Acids Res. 13, 4133–4141 (1985).
K. Hall, Ph.D. Thesis, U. of California, 1984.
H. F. Noller and J. A. Lake, Chapter 5 in Membrane Structure and Function, Vol. 6, E. E. Bittar, editor, John Wiley, New York, 1984.
H. F. Noller, Ann. Rev. Biochem. 53, 119–162 (1984).
R. R. Guttell, personal communication.
C. R. Woese, R. R. Guttell, R. Gupta and H. F. Noller, Microbiol. Revs. 47, 621–669 (1983).
M. J. Leibowitz, D. J. Thiele and E. M. Hannig, pp. 457–462 in Double Stranded RNA Viruses, R. W. Compan and D. H. L. Bishop, editors, Elsevier Science, Amsterdam, 1983.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Tinoco, I. et al. (1986). Z-RNA: A Left-Handed Double Helix. In: van Knippenberg, P.H., Hilbers, C.W. (eds) Structure and Dynamics of RNA. NATO ASI Series, vol 110. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5173-3_5
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5173-3_5
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5175-7
Online ISBN: 978-1-4684-5173-3
eBook Packages: Springer Book Archive