Abstract
Molecular genetic techniques have clarified the DNA abnormalities that cause a variety of genetic disorders. Use of restriction endonucleases, Southern blots, and DNA hybridization has made it possible to detect several types of hemoglobinopathies routinely as early as 8–10 weeks after conception. These types of studies are now being applied to the prenatal diagnosis of a growing number of other genetic disorders. Further developments will bring wider applicability and increased sensitivity, and the number and variety of disorders that will be detectable make knowledge of these tools pertinent to almost every medical subspeciality.
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© 1986 Aubrey Milunsky
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Phillips, J.A. (1986). Molecular Genetic Techniques for Prenatal Diagnosis. In: Milunsky, A. (eds) Genetic Disorders and the Fetus. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5155-9_21
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