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Neural and Endocrine Peptides and Receptors pp 581–598Cite as

Rat Islet Endocrine Cells Contain Metand Leu-Enkephalins in High- and Low-Molecular-Weight Forms

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Abstract

The rate of insulin secretion is known to be influenced by a large number of substances, including glucose and other substrates, ions, other hormones, and neurotransmitters. For example, Lerner and Porte (1971) showed that an epinephrine infusion profoundly inhibited the acute, first-phase insulin secretory response to glucose in normal humans. More recently, following the reports by Margules et al. (1978) and others (Rossier et al., 1979) of increased β-endorphin in pituitary of genetically obese hyperinsulinemic mice, evidence has begun to accumulate that suggests a role for endogenous opioid peptides in the modulation of insulin secretion and possibly in the pathophysiology of the diabetic state. Types of evidence include pharmacological studies of opiate effects on islet function, a smaller number of reports of the presence in pancreas of endogenous opioids, and a few reports suggesting that islets may secrete endogenous opioid peptides.

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Authors and Affiliations

  1. Veterans Administration Medical Center, Washington, D.C., 20422, USA

    Kim Timmers, Nancy R. Voyles, Clifford King, Michael Wells, Richard Fairtile & Lillian Recant

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  1. Kim Timmers
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  2. Nancy R. Voyles
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  3. Clifford King
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  4. Michael Wells
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  5. Richard Fairtile
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  6. Lillian Recant
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  1. The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA

    Terry W. Moody

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© 1986 Plenum Press, New York

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Timmers, K., Voyles, N.R., King, C., Wells, M., Fairtile, R., Recant, L. (1986). Rat Islet Endocrine Cells Contain Metand Leu-Enkephalins in High- and Low-Molecular-Weight Forms. In: Moody, T.W. (eds) Neural and Endocrine Peptides and Receptors. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5152-8_40

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  • DOI: https://doi.org/10.1007/978-1-4684-5152-8_40

  • Publisher Name: Springer, Boston, MA

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