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Neural and Endocrine Peptides and Receptors pp 541–552Cite as

[Norleucine3,6]-Substituted Cholecystokinin Octapeptide Analogues

Design, Synthesis, and Comparative Structure-Activity Relationships in Guinea Pig Brain, Lung, and Pancreas Tissues

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Abstract

Cholecystokinin octapeptide (CCK-8, Fig. 1) is a neurogastric peptide hormone and neurotransmitter that possesses multiple biological activities (Table I). Cholecystokinin octapeptide is one of several molecular variants (e.g., CCK-39, CCK33, CCK-12, and CCK-8) existing within a family of CCK peptides that have been identified in both the central and peripheral nervous systems as well as in the gastrointestinal tract. The specific details related to the discovery, distribution, biosynthesis, metabolism, biological activities in vitro and in vivo, and mechanisms of action of CCK peptides have been excellently reviewed recently (Mutt, 1980; Kelley and Dodd, 1981: Williams, 1982; Morley, 1982; Beinfeld, 1983; Dockray, 1983).

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Authors and Affiliations

  1. Biopolymer Chemistry/Biotechnology, The Upjohn Company, Kalamazoo, Michigan, 49001, USA

    Tomi K. Sawyer & Douglas J. Staples

  2. CNS Diseases Research, The Upjohn Company, Kalamazoo, Michigan, 49001, USA

    Robert A. Lahti, Peggy J. K. D. Schreur & Anita E. Wilkerson

  3. Lipids Research, The Upjohn Company, Kalamazoo, Michigan, 49001, USA

    Henry H. Holzgrefe & Stuart Bunting

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  1. Tomi K. Sawyer
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  1. The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA

    Terry W. Moody

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Sawyer, T.K. et al. (1986). [Norleucine3,6]-Substituted Cholecystokinin Octapeptide Analogues. In: Moody, T.W. (eds) Neural and Endocrine Peptides and Receptors. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5152-8_37

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