Abstract
There are three known genes that code for enkephalin-containing (EC) peptides (Udenfriend and Kilpatrick, 1983). The one coding for proenkephalin is expressed in many tissues. Having characterized many of the proenkephalin products and developed methods for their assay (Udenfriend et al., 1983), and having cloned bovine (Gubler et al., 1982) and rat (Howells et al., 1984) proenkephalin cDNA, we had the tools to investigate the biology of this EC peptide precursor.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Fleminger, G., Howells, R. D., Kilpatrick, D. L., and Udenfriend, S., 1984, Intact proenkephalin is the major enkephalin-containing peptide-produced in rat adrenal glands after denervation, Proc. Natl. Acad. Sci. U.S.A. 81:7985–7988.
Gubler, U., Seeburg, P., Hoffmann, B. J., Gage, L. P., and Udenfriend, S., 1982, Molecular cloning establishes proenkephalin as precursor of enkephalin-containing peptides, Nature 295:206–208.
Howells, R. D., Kilpatrick, D. L., Bhatt, R., Monahan, J. J., Poonian, M., and Udenfriend, S., 1984, Molecular cloning and sequence determination of rat preproenkephalin cDNA: Sensitive probe for studying transcriptional changes in rat tissues, Proc. Natl. Acad. Sci. U.SA. 81:7651–7655.
Howells, R. D., Kilpatrick, D. L., Noe, A., Fleminger, G., Bailey, L. C., and Udenfriend, S., 1985, Products of proenkephalin transcription and translation in mammalian heart, Fed. Proc. 44:420.
Kilpatrick, D. L., Howells, R. D., Fleminger, G., and Udenfriend, S., 1984, Denervation of rat adrenal glands markedly increases preproenkephalin mRNA, Proc. Natl. Acad. Sci. U.S.A. 81:7221–7223.
Kilpatrick, D. L., Howells, R. D., Noe, A., Bailey, L. C., and Udenfriend, S., 1985, Expression of preproenkephalin mRNA and its peptide products in mammalian testis and ovary, Proc. Natl. Acad. Sci. U.S.A. 81:7221–7223.
Schultzberg, M., Hokfelt, T., Lundberg, J., Terenius, L., Elfirm, L.-G., and Eide, R., 1978, En-kephalin-like immunoreactivity in nerve terminals in sympathetic ganglia and adrenal medulla and in adrenal medullary gland cells, Acta Physiol. Scand 103:475–477.
Udenfriend, S., and Kilpatrick, D. L., 1983, Biochemistry of the enkephalins and enkephalin-containing peptides, Arch. Biochem. Biophys. 221:309–323.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Udenfriend, S. (1986). The Enkephalin-Containing Peptides. In: Moody, T.W. (eds) Neural and Endocrine Peptides and Receptors. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5152-8_35
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5152-8_35
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5154-2
Online ISBN: 978-1-4684-5152-8
eBook Packages: Springer Book Archive