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Structure-Function Studies of Agonists and Antagonists for Gastrointestinal Peptide Receptors on Pancreatic Acinar Cells

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Neural and Endocrine Peptides and Receptors

Abstract

With the development of techniques to prepare dispersed pancreatic acini that respond to secretagogues, it became possible to investigate the cellular basis of action of the various peptides that stimulate pancreatic enzyme secretion. Various peptides differed in efficacy, potency, and configuration of their dose-response curves for stimulating enzyme secretion (Fig. 1). Pancreatic acini have receptors for different secretagogues, and with the development of techniques to prepare biologically active radiolabeled ligands for each group of structurally similar peptides, the existence of multiple classes of receptors was demonstrated directly (Fig. 2). Figure 2 summarizes the seven different classes of receptors that mediate the action of various secretagogues on pancreatic acini. Also summarized in Fig. 2 is the biochemical basis of action of each of these different receptors.

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Authors and Affiliations

  1. Digestive Diseases Branch, National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, 20205, USA

    Robert T. Jensen & Jerry D. Gardner

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  1. Robert T. Jensen
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  2. Jerry D. Gardner
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Editors and Affiliations

  1. The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA

    Terry W. Moody

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© 1986 Plenum Press, New York

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Jensen, R.T., Gardner, J.D. (1986). Structure-Function Studies of Agonists and Antagonists for Gastrointestinal Peptide Receptors on Pancreatic Acinar Cells. In: Moody, T.W. (eds) Neural and Endocrine Peptides and Receptors. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5152-8_33

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  • DOI: https://doi.org/10.1007/978-1-4684-5152-8_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5154-2

  • Online ISBN: 978-1-4684-5152-8

  • eBook Packages: Springer Book Archive

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