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Kinins as Neuropeptides

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Neural and Endocrine Peptides and Receptors

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Abstract

The kinins, including the nonapeptide bradykinin (BK) as well as several other peptide analogues of BK, have been known since their initial discovery (Rocha e Silva, 1949) to be highly active in a number of peripheral organ systems. The recent explosion of research on brain peptides has renewed interest in the possibility that kinins may also play roles as neuropeptides. In this chapter I review evidence that BK and other kinins may be acting as neuroactive peptides, especially in the central nervous system.

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References

  • Almeida de Silva, T. C., and Pela, I. R., 1978, Changes in rectal temperature of the rabbit by intracerebroventricular injection of bradykinin and related peptides, Agents Actions 8:102–107.

    Article  CAS  Google Scholar 

  • Armstrong, D., 1970, Pain, in: Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology, Vol. 25 (E. G. Erdos, ed.), Springer-Verlag, Berlin, pp. 434–481.

    Google Scholar 

  • Baccaglini, P. I., and Hogan, P. G., 1983, Some rat sensory neurons in culture express characteristics of differentiated pain sensory cells, Proc. Natl. Acad. Sci. U.S.A. 80:594–598.

    Article  PubMed  CAS  Google Scholar 

  • Barasi, S., and Wright, D. M., 1979, Effects of bradykinin on central neurons, in: Advances in Pain Research and Therapy, Vol. 3 (J. J. Bonica, ed.), Raven Press, New York, pp. 883–888.

    Google Scholar 

  • Bareis, D. L., Manganiello, V. C., Hirata, F., Vaughan, M., and Axelrod, J., 1983, Bradykinin stimulates phospholipid methylation, calcium influx, prostaglandin formation, and cAMP accumulation in human fibroblasts, Proc. Natl. Acad. Sci. U.S.A. 80:2514–2518.

    Article  PubMed  CAS  Google Scholar 

  • Belcher, G., 1979, The effects of intra-arterial bradykinin, histamine, acetylcholine and prostaglandin E1 on nociceptive and non-nociceptive dorsal horn neurones of the cat, Eur. J. Pharmacol. 56:385–395.

    Article  PubMed  CAS  Google Scholar 

  • Braas, K. M., Manning, D. C., Wilson, V. S., Perry, D. C., Stewart, J. M., Vavreck, R. J., and Snyder, S. H., 1985, Characterization of bradykinin antagonists in a cultured neuronal cell line, Neuroscience Abstr. 11:414.

    Google Scholar 

  • Buccafusco, J. J., and Serra, M., 1985, Role of cholinergic neurons in the cardiovascular responses evoked by central injection of bradykinin or angiotensin II in conscious rats, Eur. J. Pharmacol. 113:43–51.

    Article  PubMed  CAS  Google Scholar 

  • Bynke, G., Hakanson, R., Hörig, J., and Leander, S., 1983, Bradykinin contracts the pupillary sphincter and evokes ocular inflammation through release of neuronal substance P, Eur. J. Pharmacol. 91:469–475.

    Article  PubMed  CAS  Google Scholar 

  • Camargo, A. C. M., Ramalho-Pinto, F. J., and Greene, L. J., 1972, Brain peptidases: Conversion and inactivation of kinin hormones, J. Neurochem. 19:37–49.

    Article  PubMed  CAS  Google Scholar 

  • Capek, R., Masek, K., Sramka, M., Krsiak, M., and Svec, P., 1969, The similarities of the angiotensin and bradykinin action on the central nervous system, Pharmacology 2:161–170.

    Article  PubMed  CAS  Google Scholar 

  • Carretero, O. A., and Scicli, A. G., 1980, The renal kallikrein-kinin system, Am. J. Physiol. 238:F247–F255.

    PubMed  CAS  Google Scholar 

  • Chahl, L. A., and Iggo, A., 1977, The effects of bradykinin and prostaglandin Ei on rat cutaneous afferent nerve activity, Br. J. Pharmacol. 59:343–347.

    PubMed  CAS  Google Scholar 

  • Chao, J., Woodley, C., Chao, L., and Margolius, H. S., 1983, Identification of tissue kallikrein in rat brain and in the cell-free translation product encoded by rat brain mRNA, J. Biol. Chem. 258:15173–15178.

    PubMed  CAS  Google Scholar 

  • Chao, J., Chao, L., Ando, T., and Margolius, H., 1985, Kallikrein, kallikrein binding protein and kininogen in rat brain and in neuroblastoma x glioma hybrid cells, Clin. Res. 33:532A.

    Google Scholar 

  • Chapman, L. F., Ramos, A. O., Goodell, H., and Wolff, H. G., 1961, Neurohumoral features of afferent fibers in man, Arch. Neurol. 4:49–82.

    Article  Google Scholar 

  • Clark, W. G., 1979, Kinins and the peripheral and central nervous system, in: Bradykinin, Kallidin and Kallikrein, Handbook of Experimental Pharmacology, Vol. 25, Suppl. (E. G. Erdos, ed.), Springer-Verlag, Berlin, pp. 311–356.

    Google Scholar 

  • Clyman, R. I., Blacksin, A. S., Manganiello, V. C., and Vaughan, M., 1975, Oxygen and cyclic nucleotides in the human umbilical artery, Proc. Natl. Acad. Sci. U.S.A. 72:3883–3887.

    Article  PubMed  CAS  Google Scholar 

  • Correa, F. M. A., and Graeff, F. G., 1974, Central mechanisms of the hypertensive action of intra-ventricular bradykinin in the unanesthetized rat, Neuropharmacology 13:65–75.

    Article  PubMed  CAS  Google Scholar 

  • Correa, F. M. A., and Graeff, F. G., 1975, Central site of the hypertensive action of bradykinin, J. Pharmacol. Exp. Ther. 192:670–676.

    PubMed  CAS  Google Scholar 

  • Correa, F. M. A., and Graeff, F. G., 1976, On the mechanisms of the hypertensive action of intraseptal bradykinin in the rat, Neuropharmacology 15:713–717.

    Article  PubMed  CAS  Google Scholar 

  • Correa, F. M. A., Innis, R. B., Uhl, G. R., and Snyder, S. H., 1979, Bradykinin-like immunoreactive neuronal systems localized histochemically in rat brain, Proc. Natl. Acad. Sci. U.SA. 76:1489–1493.

    Article  CAS  Google Scholar 

  • Damas, J., 1972, La demi-vie de la bradykinine dans les espaces sous-arachnoides du rat, C.R. Soc. Biol. (Paris), 166:740–744.

    CAS  Google Scholar 

  • DaSilva, G. R., and Rocha e Silva, M., 1971, Catatonia induced in the rabbit by intracerebral injection of bradykinin and morphine, Eur. J. Pharmacol. 15:180–186.

    Article  CAS  Google Scholar 

  • Diz, D. I., and Jacobowitz, D. M., 1984, Cardiovascular effects of discrete intrahypothalamic and preoptic injections of bradykinin, Brain Res. Bull. 12:409–417.

    Article  PubMed  CAS  Google Scholar 

  • Douglas, W. W., 1980, Polypeptides—angiotensin, plasmakinins, and others, in: The Pharmacological Basis of Therapeutics, 6th ed. (A. Goodman Gilman, L. S. Goodman, and A. Gilman, eds.), Macmillan, New York, pp. 647–667.

    Google Scholar 

  • Erdos, E. G. (ed.), 1970, Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology, Vol. 25, Springer-Verlag, Berlin, Heidelberg, New York.

    Google Scholar 

  • Ferreira, S. H., 1972, Prostaglandins, aspirin-like drugs and analgesia, Nature 240:200–203.

    Article  CAS  Google Scholar 

  • Frederick, M. J., Vavreck, R. J., Stewart, J. M., and Odya, C. E., 1984, Further studies of myometrial bradykinin receptor-like binding, Biochem. Pharmacol. 18:2887–2892.

    Article  Google Scholar 

  • Frucht, H., Lilling, G., and Beitner, R., 1984, Influence of bradykinin on glucose 1,6-bisphosphate and cyclic GMP levels and on the activities of glucose 1,6-bisphosphatase, phosphofructokinase and phosphoglucomutase in muscle, Int. J. Biochem. 16:397–402.

    Article  PubMed  CAS  Google Scholar 

  • Goldstein, D. J., Ropchak, T. G., Keiser, H. R., Atta, G. J., Argiolas, A., and Pisano, J. J., 1983, Bradykinin reverses the effect of opiates in the gut by enhancing acetylcholine release, J. Biol. Chem. 258:12122–12124.

    PubMed  CAS  Google Scholar 

  • Graeff, F. G., and Arisawa, E. A. L., 1978, Effect of intracerebroventricular bradykinin, angiotensin II and substance P on multiple fixed-interval fixed-ratio responding in rabbits, Psychopharmacology 57:89–95.

    Article  PubMed  CAS  Google Scholar 

  • Graeff, F. G., Pela, I. R., and Rocha e Silva, M., 1969, Behavioral and somatic effects of bradykinin injected into the cerebral ventricles of unanesthetized rabbits, Br. J. Pharmacol. 37:723–732.

    PubMed  CAS  Google Scholar 

  • Hoffman, W. E., and Schmid, P. G., 1978, Separation of pressor and anti-diuretic effects of intraven-tricular bradykinin, Neuropharmacology 17:992–1002.

    Google Scholar 

  • Hori, S., 1968, The presence of bradykinin-like polypeptides, kinin-releasing and destroying activity in the brain, Jpn. J. Pharmacol. 18:772–787.

    CAS  Google Scholar 

  • Innis, R. B., Manning, D. C., Stewart, J. M., and Snyder, S. H., 1981, [3H]Bradykinin receptor binding in mammalian tissue membranes, Proc. Natl. Acad. Sci. U.S.A. 78:2630–2634.

    Article  PubMed  CAS  Google Scholar 

  • Inoki, R., Hayashi, T., Kudo, T., and Matsumoto, K., 1978, Effects of aspirin and morphine on the release of a bradykinin-like substance into the subcutaneous perfusate of the rat paw, Pain 5:53–68.

    Article  PubMed  CAS  Google Scholar 

  • Inouye, A., Kataoka, K., and Tsujioka, T., 1961, On a kinin-like substance in the nervous tissue extracts treated with trypsin, Jpn. J. Physiol. 11:319–334.

    Article  PubMed  CAS  Google Scholar 

  • Iwata, H., Shikimi, T., and Oka, T., 1969, Pharmacological significance of peptidase and proteinase in the brain: Enzymatic inactivation of bradykinin in the rat brain, Biochem. Pharmacol. 18:119–128.

    Article  PubMed  CAS  Google Scholar 

  • Iwata, H., Shikimi, T., Iida, ML, and Miichi, H., 1970, Effect of bradykinin on the central nervous system and role of the enzyme inactivating bradykinin in the mouse brain, Jpn. J. Pharmacol. 20:80–86.

    Article  PubMed  CAS  Google Scholar 

  • Iwata, T., Hashimoto, H., Hiwada, K., and Kokubu, T., 1984, Changes of plasma renin activity by intracerebroventricular administration of biologically active peptides in conscious rats, Clin. Exp. Hypertension A6:1055–1066.

    Article  CAS  Google Scholar 

  • Johnson, A. R., 1979, Effects of kinins in organ systems, in: Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology, Vol. 25, Suppl. (E. G. Erdos, ed.), Springer-Verlag, Berlin, pp. 357–399.

    Google Scholar 

  • Juan, H., and Lembeck, F., 1974, Actions of peptides and other algesic agents on paravascular pain receptors of the isolated perfused rabbit ear, Naunyn Schmiedebergs Arch. Pharmacol. 290:389–395.

    Article  Google Scholar 

  • Kariya, K., and Yamauchi, A., 1981, Effects of intraventricular injection of bradykinin on the EEG and the blood pressure in conscious rats, Neuropharmacology 20:1221–1224.

    Article  PubMed  CAS  Google Scholar 

  • Kariya, K., Iwaki, H., Ihda, M., Maruta, E., and Murasa, M., 1981, Electroencephalogram of bradykinin and its degradation system in rat brain, Jpn. J. Pharmacol. 31:261–267.

    Article  PubMed  CAS  Google Scholar 

  • Kariya, K., Yamauchi, A., and Chatani, Y., 1982a, Relationship between central actions of bradykinin and prostaglandins in the conscious rat, Neuropharmacology 21:267–272.

    Article  PubMed  CAS  Google Scholar 

  • Kariya, K., Yamauchi, A., Hattori, S., Tsuda, Y., and Okata, Y., 1982b, The disappearance rate of intraventricular bradykinin in the brain of the conscious rat, Biochem. Biophys. Res. Commun. 107:1461–1466.

    Article  PubMed  CAS  Google Scholar 

  • Kaufman, M. P., Coleridge, H. M., Coleridge, J. C. G., and Baker, D. G., 1980a, Bradykinin stimulates afferent vagal C-fibers in intrapulmonary airways of dogs, J. Appl. Physiol. 48:511–517.

    PubMed  CAS  Google Scholar 

  • Kaufman, M. P., Baker, D. G., Coleridge, H. M., and Coleridge, J. C. G., 1980b, Stimulation by bradykinin of afferent vagal C-fibers with chemosensitive endings in the heart and aorta of the dog, Circ. Res. 46:476–484.

    PubMed  CAS  Google Scholar 

  • Kellermeyer, R. W., and Graham, R. C., 1968, Kinins—possible physiologic and pathologic roles in man, N. Engl. J. Med. 279:754–759, 802-807; 859-866.

    Article  PubMed  CAS  Google Scholar 

  • Kondo, K., Okuno, T., Konishi, K., Saruta, T., and Kato, E., 1979, Central and peripheral effects of bradykinin and prostaglandin E2 in blood pressure in conscious rats, Naunyn Schmiedebergs Arch. Pharmacol. 308:111–115.

    Article  PubMed  CAS  Google Scholar 

  • Lambert, G. A., and Lang, W. J., 1970, The effects of bradykinin and eledoisin injected into the cerebral ventricles of conscious rats, Eur. J. Pharmacol. 9:383–386.

    Article  PubMed  CAS  Google Scholar 

  • Lembeck, F., Popper, H., and Juan, H., 1976, Release of prostaglandins by bradykinin as an instrinsic mechanism of its algesic effect. Naunyn Schmiedebergs Arch. Pharmacol. 294:69–73.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, G. P., and Reit, E., 1965, The action of angiotensin and bradykinin on the superior cervical ganglion of the cat, J. Physiol. (Lond.) 179:538–553.

    CAS  Google Scholar 

  • Lewis, R. E., and Phillips, M. I., 1984, Localization of the central pressor action of bradykinin to the cerebral third ventricle, Am. J. Physiol. 247:R63-R68.

    Google Scholar 

  • Lewis, R. E., Hoffman, W. E., and Phillips, M. I., 1983, Angiotensin II and bradykinin: Interactions between two centrally active peptides, Am. J. Physiol. 244:R285–R291.

    PubMed  CAS  Google Scholar 

  • Lim, R. K. S., 1970, Pain, Annu. Rev. Physiol 32:269–288.

    Article  CAS  Google Scholar 

  • Manning, D. C., and Snyder, S. H., 1983, [3H]Bradykinin receptor localization in spinal cord and sensory ganglia—evidence for a role in primary afferent function, Neurosci. Abstr. 9:590.

    Google Scholar 

  • Manning, D. C., and Snyder, S. H., 1986, [3H]Bradykinin binding site localization in guinea pig urinary system, in: Kinins IV(A) (L. M. Greenbaum and H. S. Margolius, eds.), Plenum Press, New York, pp. 561–568.

    Google Scholar 

  • Manning, D. C., Snyder, S. H., Kachur, J. F., Miller, R. J., and Field, M., 1982, Bradykinin receptor-mediated chloride secretion in intestinal function, Nature 299:256–259.

    Article  PubMed  CAS  Google Scholar 

  • McGiff, J. C., Itskovitz, H. D., Terragno, N. A., and Wong, P. Y. K., 1976, Modulation and mediation of the action of the renal kallikrein-kinin system by prostaglandins, Fed. Proc. 35:175–180.

    PubMed  CAS  Google Scholar 

  • Melo, J. C., and Graeff, F. G., 1975, Effect of intracerebroventricular bradykinin and related peptides on rabbit opérant behavior, J. Pharmacol. Exp. Ther. 193:1–10.

    PubMed  CAS  Google Scholar 

  • Moniuszko-Jakoniuk, J., Wisniewski, K., and Koscielak, M., 1976, Investigations of the mechanism of central action of kinins, Psychopharmacology 50:181–186.

    Article  PubMed  CAS  Google Scholar 

  • Nawa, H., Kitamura, N., Hirose, T., Asai, M., Inayama, S., and Nakanishi, S., 1983, Primary structures of bovine liver low molecular weight kininogen precursors and their two mRNAs, Proc. Natl. Acad. Sci. U.S.A. 80:90–94.

    Article  PubMed  CAS  Google Scholar 

  • Odya, C. E., Goodfriend, T. L., and Pena, C., 1980, Bradykinin receptor-like binding studied with iodinated analogues, Biochem. Pharmacol. 29:175–185.

    Article  PubMed  CAS  Google Scholar 

  • Okada, Y., Tuchiya, Y., Yagyu, M., Kozawa, S., and Kariya, K., 1977, Synthesis of bradykinin fragments and their effects on pentobarbital sleeping time in mouse, Neuropharmacology 16:381–383.

    Article  PubMed  CAS  Google Scholar 

  • Oliveira, E. B., Martino, A. R., and Camargo, A. C. M., 1976, Isolation of brain endopeptidases: Influence of size and sequences of substrates structurally related to bradykinin, Biochemistry 15:1967–1974.

    Article  PubMed  CAS  Google Scholar 

  • Pearson, L., Lambert, G. A., and Lang, W. J., 1969, Centrally mediated cardiovascular and EEG responses to bradykinin and eledoisin, Eur. J. Pharmacol. 8:153–158.

    Article  PubMed  CAS  Google Scholar 

  • Pela, I. R., Gardey-Levassort, C., Lechat, P., and Rocha e Silva, M., 1975, Brain kinins and fever induced by bacterial pyrogens in rabbits, J. Pharm. Pharmacol. 27:793–794.

    Article  PubMed  CAS  Google Scholar 

  • Perry, D. C., and Snyder, S. H., 1984, Identification of authentic bradykinin in mammalian brain, J. Neurochem. 43:1072–1080.

    Article  PubMed  CAS  Google Scholar 

  • Phillips, M. I., Summers, C., Lewis, R., Hoffman, L., and Casto, R., 1982, Cardiovascular effects of neuropeptides in brain and periphery, Fed. Proc. 41:1661.

    Google Scholar 

  • Phillis, J. W., and Limacher, J. J., 1974, Excitation of cerebral cortical neurons by various polypeptides, Exp. Neurol. 43:414–423.

    Article  PubMed  CAS  Google Scholar 

  • Pisano, J. J., and Austen, K. F. (eds.), 1974, Chemistry and Biology of the Kallikrein-Kinin System in Health and Disease, DHEW Publication No. NIH76-791, U.S. Government Printing Office, Washington.

    Google Scholar 

  • Regoli, D., and Barabe, J., 1980, Pharmacology of bradykinin and related kinins, Pharmacol. Rev. 32:1–46.

    PubMed  CAS  Google Scholar 

  • Reiser, G., and Hamprecht, B., 1982, Bradykinin induces hyperpolarizations in rat glioma cells and in neuroblastoma × glioma hybrid cells, Brain Res. 239:191–199.

    Article  PubMed  CAS  Google Scholar 

  • Reiser, G., Walter, U., and Hamprecht, B., 1984, Bradykinin regulates the level of guanosine 3′,5′-cyclic monophosphate (cyclic GMP) in neural cell lines, Brain Res. 290:367–371.

    Article  PubMed  CAS  Google Scholar 

  • Ribeiro, S. A., and Rocha e Silva, M., 1973, Antinociceptive action of bradykinin and related kinins of larger molecular weight by the intraventricular route, Br. J. Pharmacol. 47:517–528.

    PubMed  CAS  Google Scholar 

  • Ribeiro, S. A., DaSilva, G. R., Camargo, A. C. M., and Corrado, A. P., 1970, Hyperglycemia induced in the rabbit by intraventricular injection of bradykinin, Adv. Exp. Med. Biol. 8:635–639.

    CAS  Google Scholar 

  • Ribeiro, S. A., Corrado, A. P., and Rocha e Silva, M., 1971, Antinociceptive action of intraventricular bradykinin, Neuropharmacology 10:725–731.

    Article  PubMed  CAS  Google Scholar 

  • Rocha e Silva, M., Beraldo, W. T., and Rosenfeld, G., 1949, Bradykinin, a hypotensive and smooth muscle stimulating factor released from plasma globulin by snake venoms and by trypsin, Am. J. Physiol. 156:261–273.

    PubMed  Google Scholar 

  • Roscher, A. A., Manganiello, V. C., Jelsema, C. L., and Moss, J., 1984, Autoregulation of bradykinin receptors and bradykinin-induced prostacyclin formulation in human fibroblasts, J. Clin. Invest. 74:552–558.

    Article  PubMed  CAS  Google Scholar 

  • Shikimi, T., Kema, R., Matsumoto, M., Yamahata, Y., and Miyata, S., 1973, Studies on kinin-like substances in brain, Biochem. Pharmacol. 22:567–573.

    Article  PubMed  CAS  Google Scholar 

  • Simson, J. A. V., Dom, R., Chao, J., Chao, L., and Margolius, H. S., 1985, Immunocytochemical localization of tissue kallikrein in brain ventricular epithelium and hypothalamic cell bodies, J. Histochem. Cytochem. 33:951–953.

    Article  PubMed  CAS  Google Scholar 

  • Snider, R. M., and Richelson, E., 1984, Bradykinin receptor-mediated cyclic GMP formation in a nerve cell population (murine neuroblastoma clone NIE-115), J. Neurochem. 43:1749–1754.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, J. M., and Vavreck, R. J., 1985, Competitive antagonists of bradykinin, Peptides 6:161–164.

    PubMed  Google Scholar 

  • Stoner, J., Manganiello, V. C., and Vaughan, M., 1973, Effects of bradykinin and indomethacin on cyclic GMP and cyclic AMP in lung slices, Proc. Natl. Acad. Sci. U.S.A. 70:3830–3833.

    Article  PubMed  CAS  Google Scholar 

  • Takahashi, H., and Bunag, R. D., 1981, Centrally induced cardiovascular and sympathetic nerve responses to bradykinin in rats, J. Pharmacol. Exp. Ther. 216:192–197.

    PubMed  CAS  Google Scholar 

  • Thomas, G. R., Thibodeaux, H., Margolius, H. S., and Privitera, P. J., 1984, Cerebrospinal fluid kinins and cardiovascular function, Hypertension 6(Suppl. I): 146–150.

    Google Scholar 

  • Tomita, K., and Pisano, J. J., 1984, Binding of [3H]bradykinin in isolated nephron segments of the rabbit, Am. J. Physiol. 246:F732–F737.

    PubMed  CAS  Google Scholar 

  • Ueda, N., Muramatsu, I., and Fujiwara, M., 1984, Capsaicin and bradykinin-induced substance P-ergic responses in the iris sphincter muscle of the rabbit, J. Pharmacol. Exp. Ther. 230:469–473.

    PubMed  CAS  Google Scholar 

  • Unger, T., Rockhold, R. W., Kaufman-Buhler, I., Hubner, D., Schull, B., and Ganten, D., 1980, Effects of angiotensin concerting enzyme inhibitors on the brain, in: Angiotensin Converting Enzyme Inhibitors (Z. P. Horovitz, ed.), Urban & Schwarzenberg, Baltimore, pp. 55–79.

    Google Scholar 

  • Wahlestedt, C., Bynke, G., and Hakanson, R., 1985, Pupillary constriction by bradykinin and capsaicin: Mode of action, Eur. J. Pharmacol. 106:577–583.

    Article  Google Scholar 

  • Werle, V. E., and Zack, P., 1970, Verteilung von Kininogen in Serum und Geweben bei Ratten und anderen Sangetieren, Z. Klin. Chem. Klin. Biochem. 8:186–189.

    PubMed  CAS  Google Scholar 

  • Wilk, S., and Orlowski, M., 1979, Degradation of bradykinin by isolated neutral endopeptidases of brain and pituitary, Biochem. Biophys. Res. Commun. 90:1–6.

    Article  PubMed  CAS  Google Scholar 

  • Yang, H. Y. T., and Neff, N. H., 1972, Distribution and properties of angiotensin converting enzyme of rat brain, J. Neurochem. 19:2443–2450.

    Article  PubMed  CAS  Google Scholar 

  • Yano, K., Higashida, H., Inoue, R., and Nozawa, Y., 1984, Bradykinin-induced rapid breakdown of phosphatidylinositol 4,5-bisphosphate in neuroblastoma × glioma hybrid NG108-15 cells, J. Biol. Chem. 259:10201–10207.

    PubMed  CAS  Google Scholar 

  • Yano, K., Higashida, H., Hattori, H., and Nozawa, Y., 1985, Bradykinin-induced transient accumulation of inositol trisphosphate in neuron-like cell line NG108-15 cell, EEBS Lett. 181:403–406.

    CAS  Google Scholar 

  • Yasujima, M., Matthews, P. G., and Johnston, C. I., 1981, Regulation of uterine smooth muscle bradykinin receptors by bradykinin and angiotensin converting enzyme inhibitor in the rat, Clin. Exp. Pharmacol. Physiol. 8:515–518.

    Article  PubMed  CAS  Google Scholar 

  • Zenser, T. V., Rapp, N. S., Spry, L. A., and Davis, B. B., 1984, Independent effects of bradykinin on adenosine 3′,5′-monophosphate and prostaglandin E2 metabolism by rabbit renal medulla, Endocrinology 114:541–544.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pharmacology, George Washington University Medical Center, Washington, D. C., 20037, USA

    David C. Perry

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  1. The George Washington University School of Medicine and Health Sciences, Washington, D.C., USA

    Terry W. Moody

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Perry, D.C. (1986). Kinins as Neuropeptides. In: Moody, T.W. (eds) Neural and Endocrine Peptides and Receptors. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5152-8_25

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  • DOI: https://doi.org/10.1007/978-1-4684-5152-8_25

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