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Kinins IV pp 273–277Cite as

Regulation of Parotid Kallikrein Secretion-Role of the Alpha2- and Beta-Adrenergic System

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 198A))

Summary

The effects of pharmacologically induced alterations of alpha1, alpha2 and beta-adrenergic system on kallikrein secretion - measured as amidolytic activity - in rat parotid gland were tested in vivo. Beta and alpha1/2-adrenergic stimulation (Orciprenaline, alpha-methylnorepinephrine) caused a comparably significant increase of parotid kallikrein secretion. Alpha2-receptor blockade (yohimbine) but not the alpha1-antagonist prazosin, partly abolished the effect of alpha-methylnorepinephrine. The effects of the alpha1-adreno-receptor agonist norfenephrine on kallikrein secretion were significantly lower compared to alpha1/2-adreno-receptor-stimulation.

Parotid kallikrein secretion is preferentially dependent on beta- and alpha2-adrenergic activity.

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Authors and Affiliations

  1. Deutsche Klinik Für Diagnostik, Wiesbaden Med. Univ. Hosp., Würzburg, Germany

    Arnold Röckel, Adolf Preissler & August Heidland

Authors
  1. Arnold Röckel
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  2. Adolf Preissler
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  3. August Heidland
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Editor information

Editors and Affiliations

  1. Medical College of Georgia, Augusta, Georgia, USA

    Lowell M. Greenbaum Ph.D (President, IKC) (President, IKC)

  2. Medical University of South Carolina, Charleston, South Carolina, USA

    Harry S. Margolius Ph.D, M.D. (Vice President, IKC) (Vice President, IKC)

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© 1986 Plenum Press, New York

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Röckel, A., Preissler, A., Heidland, A. (1986). Regulation of Parotid Kallikrein Secretion-Role of the Alpha2- and Beta-Adrenergic System. In: Greenbaum, L.M., Margolius, H.S. (eds) Kinins IV. Advances in Experimental Medicine and Biology, vol 198A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5143-6_37

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  • DOI: https://doi.org/10.1007/978-1-4684-5143-6_37

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5145-0

  • Online ISBN: 978-1-4684-5143-6

  • eBook Packages: Springer Book Archive

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