Summary
The levels of high molecular weight (HMW) kininogen and pre-kallikrein in rat plasma were markedly reduced after single injection of bromelian (10 mg/kg, i. v.) and gradually recovered over a 72 hour period. The level of low molecular weight (LMW) kininogen, however, was not changed during this period.
Rat pleurisy was induced by intrapleural injection of λ-carrageenin. The levels of HMW kininogen and prekallikrein, but not of LMW kininogen, in the exudate were markedly decreased, when compared with those in plasma of the same animals.
After pretreatment with disulfiram, oral administration of ethanol (2 g/kg) or intravenous injection of acetaldehyde (10 mg/kg) to rats caused significant effect on the plasma HMW kininogen and prekallikrein levels.
These results suggest that HMW and LMW kininogens may be consumed separately in vivo and play different roles.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
E. Haberman, Kininogens, in: Handbook of Experimental Pharmacology, XXV, ed. by E. G. Erdoes, Springer-Verlag, Berlin, pp. 250–288, (1970).
K. D. Wuepper, Prekallikrein deficiency in man, J. Exp. Med., 138: 1345–1355, (1973).
H. Saito, O. D. Ratnoff, R. Waldmann, and J. P. Abraham, Fitzgerald trait: Deficiency of a hitherto unrecognized agent, Fitzgerald factor, participating in surface-mediated reactions of clotting, fibrinolysis, generation of kinins, and the property of diluted plasma enhancing vascular permeability (PF/DIL), J. Clin. Invest., 55: 1082–1089, (1975).
R. W. Colan, A. Bagdasarian, R. C. Talamo, C. F. Scott, A. M. Seavey, J. A. Guimaraes, J. V. Pierce, and A. P. Kaplan, Williams trait: Human kininogen deficiency with diminished levels of plasminogen proactivator and prekallikrein associated with abnormalities of the Hageman factor-dependent pathways, J. Clin. Invest., 56: 1650–1662, (1975).
S. Oh-ishi, A. Ueno, Y. Uchida, M. Katori, H. Hayashi, H. Koya, K. Kitajima, and I. Kimura, Abnormalities in the contact activation through factor XII in Fujiwara trait: A deficiency in both high and low molecular weight kininogens with low level of prekallikrein, Tohoku J. Exp. Med., 133: 67–80, (1981).
S. Oh-ishi and M. Katori, Fluorometric assay for plasma prekallikrein using peptidylmethylcoumarinylamide as a substrate, Thrombosis Res., 14: 551–559, (1979).
Y. Uchida and M. Katori, Differential assay method for high molecular weight and low molecular weight kininogens, Thrombosis Res., 15: 127–134, (1979).
H. Okamoto and L. M. Greenbaum, Kininogen substrates for trypsin and cathepsin D in human, rabbit and rat plasmas, Life Sci., 32: 2007–2013, (1983).
S. Oh-ishi, Y. Uchida, A. Ueno, and M. Katori, Bromelain, a thiol- protease from pineapple stem, depletes high molecular weight kininogen by activation of Hageman factor (factor XII), Thrombosis Res., 14: 665–672, (1979).
Y. Uchida, K. Tanaka, Y. Harada, A. Ueno, and M. Katori, Activation of plasma kallikrein-kinin system and its significant role in pleural fluid accumulation of rat carrageenin-induced pleurisy, Inflammation, 7: 121–131, (1983).
K. Hatake, Behavior of the kallikrein-kinin system on alcohol ingestion, Jpn. J. Alcohol & Drug Dependence, 19: 32–62, (1984) (in Japanese).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Uchida, Y., Katori, M. (1986). Independent Consumption of High and Low Molecular Weight Kininogens in Vivo. In: Greenbaum, L.M., Margolius, H.S. (eds) Kinins IV. Advances in Experimental Medicine and Biology, vol 198A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5143-6_16
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5143-6_16
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5145-0
Online ISBN: 978-1-4684-5143-6
eBook Packages: Springer Book Archive