Summary
A deficiency in the plasma kallikrein-kinin system of Brown Norway rat mutant Katholiek strain (B/N-Ka), first reported by Damas et al. was further characterized. The prolonged activated partial thromboplastin time (APTT) of B/N-Ka rat plasma was corrected by an addition of rat HMW- kininogen, indicating B/N-Ka rat is deficient in HMW kininogen.
The study of kinin-release of plasmas of the three strains of rat (B/N-ka, B/N Ki and SD) by several kininogenases expressed that B/N-Ka rat is deficient in LMW kininogen, in addition to HMW kininogen deficiency.
The plasmas of the three strains of rat were gel-filtered through Sephacryl S-200 gel and profiles of kinin-release of the fractions were examined by several kininogenases. The result demonstrated that normal rat plasma contains three kinds of kininogen (HMW and LMW kininogens, and T-kininogen), and B/N-Ka plasma contains only T-kininogen.
B/N-Ka rat plasma demonstrated T-kininogen antigen but no HMW kininogen by the study of immunodiffusion using their antisera raised in rabbits.
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© 1986 Plenum Press, New York
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Oh-ishi, S., Hayashi, I., Ino, T., Kato, H., Iwanaga, S., Nakano, T. (1986). Characterization of Kininogen Deficiency of Brown Norway Rat Mutant Katholiek Strain. In: Greenbaum, L.M., Margolius, H.S. (eds) Kinins IV. Advances in Experimental Medicine and Biology, vol 198A. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5143-6_11
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DOI: https://doi.org/10.1007/978-1-4684-5143-6_11
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