Abstract
Zona pellucida, the acellular glycoprotein envelope which surrounds the mammalian oocyte, has attracted attention as a possible antigen for immuno-contraceptive purposes. This interest is based on the demonstration that the zona pellucida contains at least one tissue specific antigen, as observed by immuno-diffusion and immunofluorescence (Sacco and Shivers 1978; Sacco 1981), SDS gel electrophoresis (Dunbar and Raynor 1980; Dunbar et al. 1981) and radio-immunoassay (Palm et al. 1979; Subramanian et al. 1981; Sacco et al. 1981; Gerrity et al. 1981).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Aitken, R.J., and Richardson, D.W., 1981, Measurement of the sperm binding capacity of the mouse zona pellucida and its use in the estimation of the anti-zona antibody titers. J. Reprod. and Fert., 63: 295.
Aitken, R.J., Rudak, E.A., Richardson, D.W. et al., 1981, The influence of anti-zona and antisperm antibodies on sperm-egg interactions. J. Reprod. and Fert., 62: 597.
Bamezai, A.K., Suman, L and Talwar, G.P., 1985, An enzyme immunoassay for zona pellucida antigens and antizona antibodies. Ind. J. Exp. Biol., Communicated.
Dunbar, B.S., and Raynor, B.D., 1980, Characterization of porcine zona pellucida antigens. Biol. Reprod., 22: 941.
Dunbar, B.S., Liu, C., and Sammons, D.W., 1981, Identification of the three major proteins of porcine and rabbit zonae pellucidae by high resolution two-dimensional gel electrophoresis: comparison with serum, follicular fluid, and ovarian cell proteins. Biol. Reprod., 24: 1111.
Gerrity, M., Niu, E., and Dunbar, B.S., 1981, A specific radioimmunoassay for evaluation of serum antibodies to zona pellucida antigens. J. Reprod. Immunol. 3: 59.
Gulyas, B.J., Gwatkin, R.B.L., and Yuan, L.C., 1983b, Active immunization of cynomolgus monkeys (Macaca fascicularis) with porcine zona pellucidae. Gamete Research, 4:299.
Gwatkin, R.B.L., Williams, D.T., and Carlo, D.J., 1977, Immunization of mice with heat-solubilized hamster zonae: production of anti-zona antibody and inhibition of fertility. Fertil. Steril., 28: 871.
Gwatkin, R.B.L., and Williams, D.T., 1978, Immunization of female rabbits with heat-solubilized bovine zonae. Production of anti-zona antibody and inhibition of fertility. Gamete Research, 1: 19.
Gwatkin, R.B.L., Anderson, O.F., and Williams, D.T., 1930, Large scale isolation of bovine and pig zonae pellucidae. Chemical, immunological and receptor properties. Gamete Research, 3: 217.
Herlands, R.L., and Schultz, R.M., 1984, Regulation of mouse oocyte growth: probable nutritional role for intercellular communication between follicle cells and oocytes in oocyte growth. J. Exp. Zool., 229 (2): 317.
Kurachi, H., Wakimoto, H., Sakumoto, T. et al., 1984, Specific antibodies to porcine zona pellucida detected by quantitative radioimmunoassay in both fertile and infertile women. Fertil. Steril., 41: 265.
Mahi-Brown, C.A., Yanagimachi, R., Hoffmann, J.D., and Huang, T.T.F., 1985, Fertility control in the bitch by active immunization with porcine zonae pellucidae: use of different adjuvants and patterns of estradiol and progesterone levels in estrous cycles. Biol. Reprod., 32: 761.
Mori, T., Nishimoto, T., Kitagawa, M. et al., 1978, Possible presence of autoantibodies to zona pellucida in infertile women. Experientia, 34: 797.
Sacco, A.G., 1977, Antigenic cross-reactivity between human and pig zona pellucida. Biol. Reprod., 21: 709.
Sacco, A.G., Shivers, C.A., 1978, Immunologic inhibition of development, in:“Methods in Mammalian Reproduction”, J.C. Daniel, Jr., ed., Academic Press, New York.
Sacco, A.G., and Moghissi, K.S., 1979, Anti-zona pellucida activity in human sera. Fertil. Steril., 31: 503.
Sacco, A.G., 1981, Immunocontraception: consideration of the zona pellucida as a target antigen, in:“Obstetrics and Gynecology Annual”, R.M. Wynn, ed., Appleton-Century-Crofts, New York.
Sacco, A.G., Subramanian, M.G., Yurewicz, E.C. et al., 1983, Heteroimmunization of squirrel monkeys (Saimiri sciureus) with a purified porcine zona antigen (PPZA): immune response and biologic activity of antiserum. Fertil Steril., 39: 350.
Shivers, C.A., and Dunbar, B.S., 1977, Autoantibodies to zona pellucida. A possible cause for infertility in women. Science, 197: 1187.
Skinner, S.M., Mills, T., Kirchick, H.J. et al., 1984, Immunization with zona pellucida proteins results in abnormal ovarian follicular differentiation and inhibition of gonadotropin-induced steroid secretion. Endocrinology, In press.
Subramanian, M.G., Yurewicz, E.C., and Sacco, A.G., 1981, A specific radioimmunoassay for the detection of a purified porcine zona pellucida antigen (PPZA). Biol. Reprod., 24: 933.
Suman, 1980, Quantitative studies on amount of anti-mouse zona pellucida antibodies required for blocking fertility in mouse. Thesis submitted for the degree of Masters in Biochemistry awarded by AIIMS, New Delhi.
Suman, 1985, Immunological properties and efficacy of Immunoglobulins induced by hetero-species zona pellucida antigen for blocking fertility in primates. Thesis submitted for award of Ph.D. degree in Biochemistry, to AIIMS, New Delhi.
Trounson, A.O., Shivers, C.A., McMaster, R., and Lopata, A., 1980, Inhibition of sperm binding and fertilization of human ova by antibody to porcine zona pellucida and human sera. Arch. Androl., 4: 29.
Tsunoda, Y., 1977, Inhibitory effect of anti mouse egg serum on fertilization in vitro and in vivo in the mouse. J. Reprod. Fertil 50 (2): 353.
Tsunoda, Y., and Chang, M.C., 1978, Effect of antisera against eggs and zona pellucida on fertilization and development of mouse eggs in vivo and in culture. J. Reprod. Fertil., 54: 233.
Tsunoda, Y., and Sugie, T., 1978, Inhibitory effect on fertilization in vitro and in vivo by zona pellucida antibody and the titration of this antibody, in: “Recent Advances in Reproduction and Regulation of Fertility”, G.P. Dalway, ed., Elsevier/North Holland Biomedical Press, Amsterdam.
Tsunoda, Y., Soma, T., and Sugie, T., 1981a, Inhibition of fertilization in cattle by passive immunization with anti-zona pellucida serum. Gamete Research, 4: 133.
Tsunoda, Y., Soma, T., Jinbu, M. et al., 1981b, Effect of anti-pig zona pellucida serum on fertilization in several mammals. Gamete Research, 4: 231.
Wood, D.M., Lui, C., and Dunbar, B.S., 1981, Effect of alloimmunization and hertoimmunization with zonae pellucidae on fertility in rabbits. Biol. Reprod., 25: 439.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Suman, Bamezai, A.K., Das, C., Talwar, G.P. (1986). Effect of Immunization of Primates Against Porcine Zonae on Fertility and Hormone Profiles. In: Talwar, G.P. (eds) Immunological Approaches to Contraception and Promotion of Fertility. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5140-5_32
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5140-5_32
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5142-9
Online ISBN: 978-1-4684-5140-5
eBook Packages: Springer Book Archive