Antigenic Profile and Impact of Immunization with Zona Pellucida Antigens in Primates
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Within the past 10–12 years numerous studies have been published which describe the investigation of zona pellucida antigens for immunocontraceptive purposes (for reviews see Sacco, 1981; Dunbar, 1983). The earliest of these studies primarily used antigens associated with rodent zonae as immunogens and involved the use of antisera developed against total zona proteins. These early in vitro experiments and passive immunization studies clearly demonstrated the contraceptive potential of antibodies produced against the zona pellucida. When the immunologic similarity of antigens present in porcine and human zona was demonstrated (Sacco, 1977), the porcine zona became a prime candidate for consideration as a target antigen for the development of a human contraceptive vaccine. The availability of large numbers of porcine ovaries as a source of zonae made this species particularly attractive for immunocontraceptive studies.
KeywordsActive Immunization Zona Pellucida Immunization Study Ovarian Follicular Development Normal Ovarian Function
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