Whence the Anti Hormones?

  • Roy Hertz
Part of the Reproductive Biology book series (RBIO)


It is a privilege to be called upon to relate to you some of the early events in the development of the endocrinologists interest in an immunological approach to fertility control.


Chorionic Gonadotropin Pituitary Hormone Pituitary Extract Hydatidiform Mole Intact Female 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Zondek, B. Die hormone des ovarioams und des hypophysenvorder lappens. Springer, Berlin, 1931.Google Scholar
  2. 2.
    Hirose, T. Exogenous stimulation of corpus luteum formation in the rabbit; influence of extracts of human placenta, decidua and hydatidiform mole. J. Japanese Gynecological Society, 16:1055, 1920Google Scholar
  3. 3.
    Fevold, H.L., Hisaw, F.L. and Leonard, S.L. The gonad-stimulating and the luteinizing hormones of the anterior lobe of the hypophysis. Am. J. Physiol., 97:291, 1931.Google Scholar
  4. 4.
    Hertz, R. and Hisaw, F.L. Effects of follicule-stimulating and luteinizing pituitary extracts on the ovaries of the infantile and juvenile rabbit. Am. J. Physiol., 108:1, 1934.Google Scholar
  5. 5.
    Selye, H. Collip, J.B., and Thomson, D.L. loss of sensitivity to anterior-pituitary-like hormone of pregnancy urine. Proc. Soc. Exp. Biol. and Med., 31:487, 1934.Google Scholar
  6. 6.
    Selye, H., Collip, J.B., and Thomson, D.L. Loss of sensitivity to the gonadotropic hormone of the hypophysis. Proc. Soc. Exp. Biol. and Med., 31:566, 1934.Google Scholar
  7. 7.
    Collip, J.B. and Anderson, E.M. The production of serum inhibitory to the thyrotropic hormone. Lancet 226:76, 1934.CrossRefGoogle Scholar
  8. 8.
    Selye, H., Bachman, C., Thomson, D.L., and Collip, J.B. Further studies on loss of sensitivity to anterior-pituitary-like hormone, Proc. Soc. Exp. Biol. and Med., 31:1113, 1934.Google Scholar
  9. 9.
    Meyer, R.K. and Gustus, E.L. Refractoriness to ovarian stimulation in rhesus monkey. Science, 81:208, 1935.PubMedCrossRefGoogle Scholar
  10. 10.
    Collip, J.B. Anterior pituitary hormones and anti-hormones. Trans. Am. Neurol. Assn., 1935, p. 7.Google Scholar
  11. 11.
    Schafer, E.A. The endocrine organs. Longmans, Green & Co., London, 1916.Google Scholar
  12. 12.
    Meyer, R.K. and Wolfe, H.R. Gonadotropic inhibitory substance and precipitins in the blood of monkeys receiving gonadotropic hormone preparations. J. Immunol., 37:91, 1939.Google Scholar
  13. 13.
    Thompson, K.W. Inability of sheep to develop antihormone to the gonadotropic hormone from sheep-pituitary glands. Proc. Soc. Exp. Biol., 35:634, 1937.Google Scholar
  14. 14.
    Du Shane et. al. Experimental “constant estrus” and notion of antigonadotropic hormones. Proc. Soc. Exp. Biol., 33: 339, 1935.Google Scholar
  15. 15.
    Werner, S.C. Prolonged injection of a thyrotropic extract without development of refractoriness. Proc. Soc. Exp. Biol., 34: 390, 1936.Google Scholar
  16. 16.
    Thompson, K.W. The augmentary factor in animal sera after injections of pituitary extract. Proc. Soc. Exp. Biol., 35: 640, 1937.Google Scholar
  17. 17.
    Rowlands, I.W. Progonadotropic sera. Proc. Roy. Soc., 13–124: 492, 1938.Google Scholar
  18. 18.
    Rowlands, I.W. Further observations on the progonadotropic and antithyrotropic activity of anti sera to extracts of the anterior pituitary gland. J. Endocrinology, 1: 177, 1939.CrossRefGoogle Scholar
  19. 18a.
    Katzman, P.A., Wade, H.J., and Doisy, E.A. Progonadotropic sera of animals treated with hypophyseal extracts. Endocrinology, 25: 554, 1939.CrossRefGoogle Scholar
  20. 19.
    Kupperman, H.S., Meyer, R.K., and Hertz, R. The effect of antigonadotropic sera upon gonadotropic secretion in parabiotic rats. Endocrinology, 24: 115, 1939.CrossRefGoogle Scholar
  21. 20.
    Meyer, R. K. and Kupperman, H.S. Hypersecretion of gonadotropic hormone of pituitary gland of rats resulting from treatment with antigonadotropic serum. Proc. Soc. Exp. Biol., 42: 285, 1939.Google Scholar
  22. 21.
    Thompson, K.W. The termination of pregnancy of dogs by gonadotropic antihormone. Endocrinology, 24: 613, 1939.CrossRefGoogle Scholar
  23. 22.
    Votquenne, M. Hypophysectomy and pregnancy in the dog. Compt. Rend. Soc. de Biol., 122: 91, 1936.Google Scholar
  24. 23.
    Hertz, R. Unpublished data.Google Scholar

Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Roy Hertz
    • 1
  1. 1.Pharmacology and Obstetrics and GynecologyThe George Washington University Medical CenterUSA

Personalised recommendations