Abstract
Neutralization of endogenous LHRH by active immunization has been reported in several species including rodents (Fraser et al, 1974) and monkeys (Chappel et al, 1980). Antibodies to LHRH inhibit LHRH presumably at the level of portal blood vessels before the hormone reaches the pituitary. Due to interception of LHRH, no LH or FSH is released thereby disrupting the production of testicular steroids and subsequently spermatogenesis in the male.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Arimura, A., Sato, H., Loy, D.H. Worobec, R.B., Schally, A.V., Yanaihara, N., Hashimoto, Y., Yanihara, C. and Sukura, H., 1975, The determinant of the LH-releasing hormone for the 3 different antisera. Acta Endocrinol (Copenhagen). 78: 222.
Arimura, A., Sato, H., Kumasaka, T., Worobec, R.B., Dunn, L., Debljuk, L. & Schally, A.V., 1973, Production of antiserum to LH-releasing hormone (LH-RH) associated with gonadal atrophy in rabbits. Development of radioimmunoassay for LHRH. Endocrinology. 93: 1092.
Carelli, C., Amdibert, F., Gaillard, D.T. & Chedid, L., 1985, Immunological Castration of male mice by a totally synthetic vaccine administered in Saline. Proc. Natl. Acad. Sci. USA. 79: 5392
Chappel, S.C., Evin Wood, B.W.E., Huckings, C., Herbert, D.C., Spies, and Spies, H.C., 1980, Active Immunization of male rhesus monkeys against luteinizing hormone releasing hormone. Biol. Reprod. 22: 333.
Copeland, K.C., Anbert, M.L., Rivier, J. & Sizonenko, P.C., 1979, Luteinizing hormone releasing hormone, releasing hormone, sequential versus conformational specificity of anti-luteinizing hormone releasing hormone sera. Endocrinology, 104: 1504.
Fraser, H.M., Gunn, A., Jeffcoate, S.L. & Holland, D.T., (1974) Effect of active immunization to luteinizing hormone releasing hormone on serum and pituitary gonadotropins, testes and accessory sex organs in the male rat. J. Endocrinology. 63: 339.
Kerdeltue, B., Catin, S. Kordon, C. & Jutisy, M., 1976, Delayed effects of in vivo LH-RH immuno neutralization of gonadotropins and prolactin secretion in the female rats. Endocrinology. 98: 1539.
Koch, Y., Wilchek, M., Fridkin, M., Chobsung, P. Zor, V. & Lindner, H. R., 1973, Production and characterization of an antiserum to synthetic gonadotropin releasing hormone. Biochem. Biophy. Res. Commun. 616.
Shastri, N., Manhar, S.K. & Talwar, G.P., 1981, Important role of the carrier in the induction of antibody response without Freund’s complete adjuvant against a “self” peptide luteinizing hormone releasing hormone (LHRH). Am. J. Reprod. Immunol. 1: 262.
Singh, V., Singh, O., Kaul, S. & Talwar, G.P., 1985, The dominant role of amide group at C-terminus for recognition by antibody in primates against gonadotropin releasing hormone. J. Steroid. Biochem. In Press
Sternberger, L.A., Petrali, J.P., Joseph, S.A., Meyer, H.G. & Mills, K.R., 1978 specificity of the immunocytochemical luteinizing hormone releasing hormone receptor reaction. Endocrinology 102: 63.
Talwar, G.P., Gupta, S.K., Singh, V., Sahal, D., Iyer, K.S.N. and Singh O., 1985, Bioeffective monoclonal antibody against the decapeptide gonadotropin-releasing hormone: Reacting determinant and action on ovulation and estrus suppression. Proc. Natl. Acad. U.S.A. 82: 1228.
Tennissen, B., Thomas, K. & Ferin, J., Coupling of carboxyme thylated (Itis)2., 1976, luteinizing hormone releasing hormone to poly-DL-alanine chains (tracer groups) polymerised on human lactroferrin FEBS Le 72: 341.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Shaha, C. et al. (1986). Immunization Against LHRH Without the Use of Freund’s Complete Adjuvant. In: Talwar, G.P. (eds) Immunological Approaches to Contraception and Promotion of Fertility. Reproductive Biology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5140-5_17
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5140-5_17
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5142-9
Online ISBN: 978-1-4684-5140-5
eBook Packages: Springer Book Archive