Immunization Against LHRH Without the Use of Freund’s Complete Adjuvant
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Neutralization of endogenous LHRH by active immunization has been reported in several species including rodents (Fraser et al, 1974) and monkeys (Chappel et al, 1980). Antibodies to LHRH inhibit LHRH presumably at the level of portal blood vessels before the hormone reaches the pituitary. Due to interception of LHRH, no LH or FSH is released thereby disrupting the production of testicular steroids and subsequently spermatogenesis in the male.
KeywordsLuteinizing Hormone Seminiferous Tubule Tetanus Toxoid Luteinizing Hormone Release Hormone Muramyl Dipeptide
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