LHRH Immunoneutralization: Basic Studies and Prospects for Practical Application

  • Hamish M. Fraser
Part of the Reproductive Biology book series (RBIO)


The hypothalamic decepeptide, pG1u-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-G1y-NH2, luteinizing hormone releasing hormone (LHRH) or gonadotrophin releasing hormone, plays a central role in reproduction in all mammalian species. Our understanding of its physiological role has been guided on one hand by effects of administering LHRH at different doses and frequencies to humans or experimental animals who lack the hormone, and on the other by studying the consequences of desensitizing the pituitary by repeated exposure to agonist analogues, by blocking the LHRH receptors by chemical antagonists or by the neutralizing endogenous LHRH by antibodies (Fig. 1). These studies have shown that for continued stimulation, the pituitary gonadotroph must be exposed to small pulses of LHRH at a frequency of one per 60–120 min (1–3) which appear to the pattern of normal hypothalamic activity as reflected by the frequency of luteinizing hormone (LH) pulses from the pituitary gland and from what is known from measuring LHRH in the hypophysial portal blood (4).


Luteinizing Hormone Follicle Stimulate Hormone Passive Immunization Luteinizing Hormone Release Hormone Gonadotrophin Secretion 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Hamish M. Fraser
    • 1
  1. 1.MRC Reproductive Biology UnitEdinburghUK

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