Immunization Against FSH as a Method of Male Contraception
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In May 1985 I had the opportunity of participating in an International Workshop on Male Contraception in Geneva, Switzerland sponsored by the Program for Applied Research on Fertility Regulation (PARFR), Northwestern University. PARFR invited Professor Eberhard Nieschlag of the Max Planck Clinical Research Unit for Reproductive Medicine, Munster, Federal Republic of Germany, to present a paper on immunization against FSH as a male method of fertility regulation. Professor Nieschlag informed PARFR that the results of his work in this area were discouraging and that his group had abandoned the approach. Not dissuaded by negative results, PARFR reinvited Professor Nieschlag to present a paper on the reasons for abandoning immunization against FSH as an approach to male fertility regulation.(1) Because Professor Nieschlag was unable to attend the Fogerty Symposium I would like to summarize some of his findings for you.
KeywordsCynomolgus Monkey Sperm Count Testicular Volume Fertility Regulation Testosterone Enanthate
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- 1.E., Nieschlag, Reasons for abandoning immunization against FSH as an approach to male fertility regulation, in: “Male Contraception: Advances and Future Prospects,” G. I. Zatuchni, A. Goldsmith, J. J. Sciarra and J. M. Spieler, eds., Harper and Row, Philadelphia (1986, in preparation).Google Scholar
- 4.H.G.M., Raj, Murty, G.S.R.C., Sairam, M.R. and Talbert, L.M., Control of spermatogenesis in primates: Effects of active immunization against FSH in the monkey, Int. J. Androl., Suppl. 5:27 (1982).Google Scholar
- 5.G.S.R.C., Murty, Rani, C.S.S., Moudgal, N.R. and Prasad, M.R.N., Effect of passive immunization with specific antiserum to FSH on the spermatogenesis process and fertility of adult male bonnet monkeys (Macaca radiata), J. Reprod. Fertil., Suppl. 26:147 (1979)Google Scholar
- 6.N.R. Moudgal, — This SymposiumGoogle Scholar