Development of oFSH as a Vaccine for the Male — A Status Report on the Recent Reasearches Carried Out Using the Bonnet Monkey (M. Radiata)
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It is currently accepted that immunocontraception is a feasible procedure for the female. The possibility of using such an approach in the male is still under experimental manipulation. Among the different immunogens suggested three antigens — one tissue specific and two hormonally based appear promising and as such are currently being tested. Development of any contraceptive for the male has to contend with the effect it may have on testosterone production and consequently libido. Most hormonally based contraceptives under development for the male therefore advocate supplementation with an androgen. The one exception to this appears to be FSH. The observation that FSH is involved in regulating sperm production and fertility of the adult male primate in itself is of recent origin. It was shown in 1979 that continuous neutralization of endogenous FSH of proven fertile adult male bonnet monkeys over a period of 90–230 days with characterized FSH antibody effects testicular funcion, the monkeys becoming infertile as a consequence of it1–4. Such neutralization, however, did not effect testosterone production or libido. This basic observation particularly with respect to the effect passive immunization with FSH antiserum produces on the quality and quantity of sperm production was soon confirmed using the rhesus5 and cynomolgous6 monkeys. Yet another evidence for the involvement of FSH in regulating testicular function of the adult male primate was obtained recently by chronically dosing adult proven fertile male bonnet monkeys with an ovine testicular inhibin preparation.
KeywordsPassive Immunization Sperm Production Testicular Function Bonnet Monkey Total Sperm Count
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- 2.G.S.R.C. Murty, C.S. Sheela Rani, N.R. Moudgal, and M.R.N. Prasad, Effect of passive immunization with specific antiserum to FSH on the spermatogenic process and fertility of adult male bonnet monkeys (Macaca radiata), J. Reprod. Fert., Suppl. 26:147 (1979).Google Scholar
- 3.G.S.R.C. Murty, C.S. Sheela Rani, and N.R. Moudgal, The role of FSH in regulating testicular function — a study involving the use of specific FSH antibodies, Proc. VI Intl. Cong. Endocrinol., Melbourne Australia (1980).Google Scholar
- 6.H.G.M. Raj, M.R. Sairam, M. Dym, N. Kotite, F.S. French, C. Sloan, and R. Chendy, Effect of immunization against follicle stimulating hormone on spermatogenesis in the rat and the monkey, in: “Nonhuman primate models for study of human reproduction”, T.C. Anand Kumar, ed., Karger (Basel), (1980).Google Scholar
- 7.N.R. Moudgal, H.M. Shashidhara Murthy, G.S. Murthy, and A.J. Rao, A role-for inhibin in regulating FSH levels in the adult male bonnet monkey, Proc. of Satellite Symposium on Gonadal Protein and Quebec, Canada, World Scientific Publishers, Singapore, p21 (1984).Google Scholar
- 9.H.G.M. Raj, Effefct of active immunization with FSH on spermtogenesis in the adult crab eating monkey — evaluation for male contraception, See chapter in this book.Google Scholar
- 10.C. S. Sheela Rani, N. Ravindranath, and N.R. Moudgal, Role of FSH in follicular development in the bonnet monkey: studies using an antiserum to FSH, Proc. 7th Intl. Cong. Endocrinol. (1984).Google Scholar