Rational Vaccine Design: Opportunities Offered by Molecular Genetics

  • N. A. Mitchison
Part of the Reproductive Biology book series (RBIO)


The issue discussed here is how current knowledge of immunoregulation can help design safe and effective birth control vaccines. The principle questions are (i) how to obtain an effective response in terms of magnitude and duration, (ii) how to avoid generating autoimmunity to self-components of the body, (iii) how to avoid anamnastic immunity (avoiding boosting of the response eg by incipient pregnancy, in order to ensure that vaccination is reversible), and (iv) how much new modes of vaccination, such as using vaccinia as a vector, have to offer. This discussion will centre round the two immunological mechanisms which are central to all vaccine development, differentiation of epitopes as suppressors or helpers, and intrastructural antigenic competition. Fig. 1 Regulation of the B-cell responses


Immunological Memory Receptor Immunoglobulin Imperial Cancer Research Fund Principle Question Dual Recognition 
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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • N. A. Mitchison
    • 1
  1. 1.Imperial Cancer Research Fund, Tumour Immunology Unit Department of ZoologyUniversity College LondonLondonUK

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