Abstract
The mechanisms by which chemicals produce tissue damage include, for example, biotransformation to reactive, electrophilic metabolites, initiation of lipid peroxidation, and formation of toxic, reduced oxygen metabolites. The liver, because of its abundant capacity for biotransformation, is frequently the target organ for chemicals whose toxicity is associated with bioactivation. Extrahepatic target organs are well known, and this toxicity may also be associated with target organ bioactivation.
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© 1986 Plenum Press, New York
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Anders, M.W., Lash, L.H., Elfarra, A.A. (1986). Nephrotoxic Amino Acid and Glutathione S-Conjugates: Formation and Renal Activation. In: Kocsis, J.J., Jollow, D.J., Witmer, C.M., Nelson, J.O., Snyder, R. (eds) Biological Reactive Intermediates III. Advances in Experimental Medicine and Biology, vol 197. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5134-4_43
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DOI: https://doi.org/10.1007/978-1-4684-5134-4_43
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