Abstract
Alzheimer disease (AD) is an early onset dementia (patient under the age of 65 at the time of onset) characterized clinically by an initial loss of memory for recent events, with a later deterioration of cognition, memory and personality (Katzman, 1976; Terry & Davies, 1980; Wiskniewski & Iqbal, 1980). At a gross anatomical level, the brains of patients with AD are generally smaller than those of controls and usually show atrophy of the temporal and frontal lobes. At a histological level, the disorder is characterized by the presence of plaques, consisting of abnormal neurites associated with extracellular amyloid (Wisniewski & Terry, 1976; Tomlinson, 1982) and neurofibrillary tangles, comprised of paired helical filaments, which are concentrated in the perikarya (cell bodies) of neurones (Kidd, 1963; Tomlinson, 1982).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Balmain, A., Krumlauf, R., Vass, J.K. and Birnie, G.G. (1982) Nucl. Acids Res. 10 4259–4277.
Borthwick, N.M., Yates, C.M. and Gordon, A. (1985) J. Neurochem. 44 1436–1441.
Cross, A.J., Crow, T.J., Perry, E.K., Perry, R.H., Blessed, G. and Tomlinson, B.E. (1981) Br. Med. J. 282 93–94.
Curtis, A., Lyons, V. and Fink, G. (1985) J. Endocrinol. 105 163–168.
Davies, P. (1979) Brain Res. 171, 319–327.
Davies, P., Katzman, R. and Terry, R.D. (1980) Nature 288, 279–280
Hardy, J., Adolfsson, R., Alafuzoff, I., Bucht, G., Marcusson, J., Nyberg, P., Perdahl, E., Wester, P. and Winblad, B. (1985) Neurochem. Int. 7, 545–563.
Kaplan, B.B., Bernstein, S.L. and Gioios, A.E. (1979) Biochem. J. 183 181–184.
Katzman, R. (1976) Arch. Neurol. 33 217–218
Kidd, M. (1963) Nature 197, 192–193
Kosik, K.S., Gilbert, J.M., Selkoe, D.J. and Strocchi, P. (1982). J. Neurochem. 39 1529–1538.
Maniatis, T, Fritsch, E.F. and Sambrook, J. (1982) In: Molecular Cloning pp. 202–203, Cold Spring Harbour Laboratory, New York.
Marotta, C.A. and Sajdel-Sulkowska, E.M. (1983). J. Neurochem. 41, suppl. 520A.
O’Farrell, P.H. (1975) J. Biol. Chem. 250 4007–4021.
Pelham, H.R.B. and Jackson, R.J. (1976) Eur. J. Biochem. 17 328–338.
Sajdel-Sulkowska, E.M. and Marotta, C.A. (1984) Science 225 947–949.
Selkoe, D.J. (1980) Ann. Neurol. 8 465–478.
Taylor, J.B., Craig, R.K., Beale, D. and Ketterer, B. (1984). Biochem. J. 219, 223–231.
Terry, R.D. and Davies, P. (1980) Ann. Rev. Neurosci. 3 77–95.
Tomlinson, B.E. (1982) Psychol. Med. 12 449–459.
White, P. Hiley, C.R., Goodhardt, M.J., Carrasco, L.H., Keet, J.P., Williams, I.E.I, and Bowen, D.M. (1977) Lancet i 668–671.
Wisniewski, H.M. and Iqbal, K. (1980) Trends Neurose. 3 226–228.
Yates, C.M., Harmar, A.J., Rosie, R., Sheward, J., Sanchez de Levy, G, Simpson, J., Maloney, A.F.J., Gordon, A. and Fink, G. (1983) Brain Res. 258 45–52.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Pascall, J.C., Borthwick, N.M., Curtis, A., Lyons, V., Yates, C.M. (1986). Comparison of Protein and Ribonucleic Acid Composition of Post Mortem Brain Tissue Between Controls and Cases of Alzheimer Type Dementia. In: Fink, G., Harmar, A.J., McKerns, K.W. (eds) Neuroendocrine Molecular Biology. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5131-3_38
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5131-3_38
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5133-7
Online ISBN: 978-1-4684-5131-3
eBook Packages: Springer Book Archive