Abstract
The role of luteinizing hormone releasing hormone (LHRH) and the pituitary gonadotrophins in controlling progesterone secretion from the corpus luteum of the human and the non-human primates is one of the most important fundamental questions concerning the hypothalamo-pituitary-ovarian axis still to be resolved. An understanding of this inter-relationship would help in the development of a way of reliably preventing progesterone production from the corpus luteum necessary for the establishment and maintenance of early pregnancy.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Asch, R.H., Abou-Samra, M., Braunstein, G.D. and Pauerstein, C.J. Luteal function in hypophysectomized rhesus monkeys. J. Clin. Endocr. Metab. 55:154 (1982).
Asch, R.H., Sickle, M.V., Rettori, V., Balmaceda, J.P., Eddy, C.A., Coy, D.H. and Schally, A.V. Absence of LH-RH binding sites in corpora lutea from rhesus monkeys (Macaca mulatta). J. Clin. Endocr. Metab. 53:215 (1981).
Balmaceda, J.P., Borghi, M.R., Coy, D.H., Schally, A.V. and Asch, R.H. Suppression of postovulatory gonadotrophin levels does not affect corpus luteum function in rhesus monkeys. J. Clin. Endocr. Metab. 57:866 (1983).
Belisle, S., Guerin, J.F., Bellabarba, D. and Lehoux, J.G. Luteinizing hormone-releasing hormone binds to enriched human placental membranes and stimulates in vitro the synthesis of bioactive human chorionic gonadotripin. J. Clin. Endocr. Metab. 59:119 (1984).
Casper, R.J., Erickson, G.F. and Yen, S.S.C. Studies on the effect of gonadotropin-releasing hormone and its agonist on human luteal steroidogenesis in vitro. Fertil. Steril. 42:39 (1984).
Clayton, R.N., Harwood, J.P. and Catt, K.J. Gonadotrophin-releasing hormone analogue binds to luteal cells and inhibits progesterone production. Nature 282:90 (1979).
Clayton, R.N. and Huhtaniemi, I.T. Absence of gonadotrophin-releasing hormone receptors in human gonadal tissue. Nature 299:56 (1982).
Currie, A.F., Fraser, H.M. and Sharpe, R.M. Human placental receptors for luteinizing hormone releasing hormone. Biochem. Biophys. Res. Commun. 99:323 (1981).
Ellinwood, W.E., Norman, R.L. and Spies, H.G. Changing frequency of pulsatile luteinizing hormone and progesterone secretion during the luteal phase of the menstrual cycle of rhesus monkeys. Biol. Reprod. 31:714 (1984).
Filicori, M., Butler, J.P. and Crowley, W.F. Neuroendocrine regulation of the corpus luteum in the human. Evidence for pulsatile progesterone secretion. J. Clin. Invest. 73:1638 (1984).
Fraser, H.M., Baird, D.T., McRae, G.I., Nestor, J.J. and Vickery, B.H. Suppression of luteal progesterone secretion in the stumptailed macaque by an antagonist analogue of luteinizing hormone releasing hormone. J. Endocr. 104:R1 (1985).
Fraser, H.M., McNeilly, A.S. and Popkin, R.M. In: “Immunological Aspects of Reproduction in Mammals” ed B. Crighton. Butterworths. pp399-418 (1984).
Groff, T.R., Madhwa Raj, H.G., Talbert, L.M. and Willis, D.L. Effects of neutralization of luteinizing hormone on corpus luteum function and cyclicity in Macaca fasicularis. J. Clin. Endocr. Metab. 59:1054 (1984).
Healy, D.L., Schenken, R.S., Lynch, A., Williams, R.F. and Hodgen, G.D. Pulsatile progesterone secretion: its relevance to clinical evaluation of corpus luteum function. Fertil. Steril. 41:114 (1984).
Hutchison, J.S. and Zeleznik, A.J. The rhesus monkey corpus luteum is dependent on pituitary gonadotrophin secretion throughout the luteal phase of the menstrual cycle. Endocrinology 115:1780 (1984).
Hsueh, A.J. and Jones, P.B.C. Extrapituitary actions of gonadotrophin-releasing hormone. Endocr. Rev. 2:437 (1981).
Knobil, E. The neuroendocrine control of the menstrual cycle. Rec. Prog. Horm. Res. 36:53 (1980).
Kohdr, G. and Siler-Khodr, T.M. The effect of luteinizing hormone-releasing factor on human chorionic gonadotrophin secretion. Fertil. Steril. 30:301 (1978).
Lincoln, D.W., Fraser, H.M., Lincoln, G.A., Martin, G.B. and McNeilly, A.S. Hypothalamic pulse generators. Rec. Prog. Horm. Res. 41:369 (1985).
Moudgal, N.R., MacDonald, G.J. and Greep, R.O. Role of endogenous primate LH in maintaining corpus luteum function in the monkey. J. Clin. Endocr. Metab. 35:113 (1972).
Nestor, J.J., Tahilramani, R., Ho, T.L., McRae, G., Vickery, B.H. and Bremner, W.J. In: “Peptides: Structure and Function”. Proceedings of the 8th American Peptide Symposium, pp861–864. Eds V.J. Hruby and D.H. Rich. Rockford, Illinois: Pierce Chemical Co (1983).
Popkin, R., Bramley, T.A., Currie, A., Shaw, R.W., Baird, D.T. and Fraser, H.M. Specific binding of luteinizing hormone releasing hormone to human luteal tissue. Biochem. Biophys. Res. Commun. 14:750 (1983).
Siler-Khodr, T.M., Khodr, G.S., Vickery, B.H. and Nestor, J.J. Inhibition of hCG, hCG and progesterone release from human placental tissue in vitro by a GnRH antagonist. Life Sci. 32:241 (1983).
Van de Wiele, R.L., Bogumil, J., Dyrenfurth, I., Ferin, M., Jewelerwicz, R., Warren, M., Rizkallah, T. and Mikhail, G. Mechanisms regulating the menstrual cycle in women. Rec. Prog. Horm. Res. 26:63 (1970).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1986 Plenum Press, New York
About this chapter
Cite this chapter
Fraser, H.M., Abbott, M., Laird, N.C. (1986). Effects of an LHRH Antagonist on Luteal Function in the Macaque. In: Fink, G., Harmar, A.J., McKerns, K.W. (eds) Neuroendocrine Molecular Biology. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5131-3_37
Download citation
DOI: https://doi.org/10.1007/978-1-4684-5131-3_37
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-5133-7
Online ISBN: 978-1-4684-5131-3
eBook Packages: Springer Book Archive