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Biochemical and Functional Characterization of GnRH Receptors

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Neuroendocrine Molecular Biology

Part of the book series: Biochemical Endocrinology ((BIOEND))

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Abstract

The primary regulator of the reproductive cycle is the hypothalamic decapeptide gonadotropin-releasing hormone (GnRH) which stimulates gonadotropin release from the anterior pituitary. The first step in GnRH action (Conn et al., 1981b) is its recognition by specific binding sites (receptors) at the surface of gonadotrope cells. The interaction of GnRH with pituitary membrane preparations or cultured pituitary cells has indicated the presence of a single class of high-affinity binding sites for both agonists and antagonists of GnRH (Clayton et al., 1978; Conne et al., 1979; Clayton and Catt, 1980, 1981; Marian and Conn, 1980; Naor et al., 1980; Hazum, 1981a; Marian et al., 1981; Meidan and Koch, 1981). Since the binding properties of GnRH receptors have been studied in detail, this review will be focussed on recent studies related to biochemical and functional characterization of pituitary GnRH receptors.

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Author information

Authors and Affiliations

  1. Department of Hormone Research, The Weizmann Institute of Science, Rehovot, 76100, Israel

    Eli Hazum, Iris Schvartz & Dana Keinan

Authors
  1. Eli Hazum
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  2. Iris Schvartz
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  3. Dana Keinan
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Editors and Affiliations

  1. MRC Brain Metabolism Unit, Edinburgh, Scotland

    G. Fink  & A. J. Harmar  & 

  2. The International Foundation for Biochemical Endocrinology, Blue Hill Falls, Maine, USA

    Kenneth W. McKerns

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© 1986 Plenum Press, New York

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Hazum, E., Schvartz, I., Keinan, D. (1986). Biochemical and Functional Characterization of GnRH Receptors. In: Fink, G., Harmar, A.J., McKerns, K.W. (eds) Neuroendocrine Molecular Biology. Biochemical Endocrinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-5131-3_33

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  • DOI: https://doi.org/10.1007/978-1-4684-5131-3_33

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-5133-7

  • Online ISBN: 978-1-4684-5131-3

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